“…Afterward, outperforming model(s) may be selected by comparing the average of the performance measures (such as sensitivity, specificity, precision, negative predictive value, AUC, positive and negative likelihood ratios, and Youden's index) obtained from cross‐validation (Collins et al, 2015; Moons et al, 2019). In the event of multiple models with good accuracy, a correlation analysis of their outputs may be performed to determine whether constructing a voting or stacking ensemble model that incorporates outputs from each of them is warranted (Adeoye et al, 2023; Tang et al, 2022). The final AI‐assisted biomarker‐based model may then be investigated to determine their accuracy, calibration, and net benefit for predicting disease outcomes in independent patient samples before a PRoBE trial is conducted.…”