BACKGROUND: The study goal was to develop and test the effectiveness of a brief online education and support program for female infertility patients. METHODS: A randomized-controlled trial was conducted. Using a Solomon-four group design, 190 female patients were recruited from three US fertility centers and were randomized into two experimental and two no-treatment control groups. The psychological outcomes assessed included infertility distress, infertility self-efficacy, decisional conflict, marital cohesion and coping style. Program dosage and satisfaction were also assessed at four weeks follow-up. RESULTS: Women exposed to the online program significantly improved in the area of social concerns (P 5 0.038) related to infertility distress, and felt more informed about a medical decision with which they were contending (P 5 0.037). Trends were observed for decreased global stress (P 5 0.10), sexual concerns (P 5 0.059), distress related to child-free living (P 5 0.063), increased infertility selfefficacy (P 5 0.067) and decision making clarity (P 5 0.079). A dosage response was observed in the experimental groups for women who spent >60 min online for decreased global stress (P 5 0.028) and increased self efficacy (P 5 0.024). CONCLUSIONS: This evidence-based eHealth program for women experiencing infertility suggests that a web-based patient education intervention can have beneficial effects in several psychological domains and may be a cost effective resource for fertility practices.