This study aims to examine social network sites acceptance in an e-Learning system and to propose a model encompassing determining factors that affect students' intentions to use social network sites in the e-Learning system. The proposed model was built based on the Technology Acceptance Model (TAM), perceived enjoyment, social influences, and perceived information security from the literature review. The quantitative method of data collection using a questionnaire survey is used in the current study. The data analysed using a structural equation modeling (SEM) approach through partial least square (PLS) software version 3. The results indicated that perceived ease of use, perceived usefulness, perceived enjoyment, social influences, and perceived information security has a significant and positive impact on student's acceptance of social network sites in an e-Learning system at Palestine Technical University-Kadoorie. Theoretical and practical implications discussed.