Explicit memory in pregnant women

Keenan, P. A.; Yaldoo, D. T.; Stress, Maureen; Fuerst, Darren R.; Ginsburg, Kenneth A.

doi:10.1016/s0002-9378(98)70073-0

Cited by 91 publications

(72 citation statements)

References 18 publications

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“…2 For instance, explicit memory [3][4][5] and mood [4][5][6] deteriorate during pregnancy when progesterone and estradiol levels reach their highest physiological concentrations. Mood is also influenced by the more subtle changes in these hormone levels during the menstrual cycle.…”

Section: Introductionmentioning

confidence: 99%

Progesterone selectively increases amygdala reactivity in women

et al. 2007

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The acute neural effects of progesterone are mediated by its neuroactive metabolites allopregnanolone and pregnanolone. These neurosteroids potentiate the inhibitory actions of c-aminobutyric acid (GABA). Progesterone is known to produce anxiolytic effects in animals, but recent animal studies suggest that pregnanolone increases anxiety after a period of low allopregnanolone concentration. This effect is potentially mediated by the amygdala and related to the negative mood symptoms in humans that are observed during increased allopregnanolone levels. Therefore, we investigated with functional magnetic resonance imaging (MRI) whether a single progesterone administration to healthy young women in their follicular phase modulates the amygdala response to salient, biologically relevant stimuli. The progesterone administration increased the plasma concentrations of progesterone and allopregnanolone to levels that are reached during the luteal phase and early pregnancy. The imaging results show that progesterone selectively increased amygdala reactivity. Furthermore, functional connectivity analyses indicate that progesterone modulated functional coupling of the amygdala with distant brain regions. These results reveal a neural mechanism by which progesterone may mediate adverse effects on anxiety and mood.

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Section: Introductionmentioning

confidence: 99%

Progesterone selectively increases amygdala reactivity in women

et al. 2007

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“…Pregnancy is characterized by dramatic hormonal fluctuations, including unusually high levels of estrogen, progesterone, oxytocin, and other hormones [15]. Pregnant women report [5,10,35,42] and demonstrate [6,26,42,47] impaired explicit memory for words (but see [5]). Studies of implicit memory in pregnancy provide less consistent results, even among studies using the same test of lexical implicit memory (i.e.…”

Section: Introductionmentioning

confidence: 99%

Implicit memory varies across the menstrual cycle: estrogen effects in young women

2002

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Evidence that ovarian steroid hormones such as estrogen and progesterone affect cognition comes from studies of memory in older women receiving estrogen replacement therapy and studies of sexually dimorphic skills in young women across the menstrual cycle. Sixteen women (ages 18-28) completed tests of memory (implicit category exemplar generation, category-cued recall, implicit fragmented object identification) and sexually dimorphic skills (fine motor coordination, verbal fluency, mental rotations) at the early follicular (low estrogen and progesterone) and midluteal (high estrogen and progesterone) phases of the menstrual cycle. Performance on category exemplar generation, a test of conceptual implicit memory, was better at the midluteal than the follicular phase. In contrast, performance on a test of explicit memory, category-cued recall, did not vary across the menstrual cycle. At Session 1, women in the follicular phase performed better on the fragmented object identification task than did those in the midluteal phase. This unexpected finding suggests that high levels of ovarian hormones might inhibit perceptual object priming. Results confirmed previous reports of decreased mental rotations and improved motor skills and fluency in the midluteal phase. Estradiol levels correlated positively with verbal fluency and negatively with mental rotations and perceptual priming, which suggest that estrogen, and not progesterone, was responsible for the observed changes in cognition. Mood did not vary across the cycle phases. Overall, the findings suggest that estrogen may facilitate the automatic activation of verbal representations in memory.

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“…6 It was a longitudinal study designed to investigate memory in women throughout pregnancy and in the postpartum period. Contrasts showed a significant decline in memory for the pregnant group from the second to the third trimester (P < .01).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Eidelman et al and few others have put forth presence of impairment in cognition post parturition. [5][6][7] This study aimed to fill the void that is left behind from previous studies (i.e.) to assess the exact time during the peripartum period where this impairment is at its maximum and establishing a possible relationship to blood indices, which serves as a indirect study of hormonal relationship to this study.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of relationship between memory functions and blood indices across parturition in primigravidae

Srinivasan

Meerasa

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPsychoneuroendocrinology is a nascent and vibrant field of endocrinology, revealing the unexplored paths of the diversifying field relating to cognitive functions and blood indices which is an interesting learning arena. During the period of pregnancy, women undergo various physical stress factors such as exertion and fatigue. In accordance with the available literature, these factors have been linked with cognitive impairment which is believed to be the result of increased levels of corticosteroids, Oxytocin, and endogenous opiates (substances associated with conception and parturition). 1,2Betaendorphins, substance associated with conception ABSTRACT Background: Psychoneuroendocrinology is a nascent and vibrant field of endocrinology, revealing the unexplored paths of the diversifying field relating to cognitive functions and blood indices which is an interesting learning arena. This work, establishes the relationship of cognitive status and blood indices across parturition among the same subjects. Methods: The experimental design aimed at administration of cognitive assessment function tests as per Wechsler's memory scale to pregnant subjects and getting specific blood parameters analysed across parturition. The statistical analysis included regression analysis to eliminate the effect of age on the parameters considered and a paired T test to establish relationship across parturition among the same subjects. Results: Cognitive assessment of the subjects clearly revealed that the following aspects of cognitive functions during conception are significantly impaired post parturition general memory, mental control 1, 2, 3, immediate recall memory. (Mental control 4 and 5). Symbolic memory (observations). Whereas the following cognitive functions of the same subjects during conception, are NOT significantly impaired post parturition, orientation, digit cognition (mental control 6 and 7). In the case of blood indices, as per the results obtained, it is quite clearly evident that the following blood parameters of the same subjects showed statistically significant difference during conception compared to post parturition. Mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV). Whereas the following blood parameters of the same subjects showed NO statistically significant difference during conception compared to post parturition, haemoglobin (Hb), total count (TC), platelet count (PC) Conclusions: The domain of cognition related to immediate and recent memory functions, Mean corpuscular blood indices have shown significant variation during pregnancy compared to post parturition. Therefore, the parameters considered in this study indirectly reflects upon the hormonal influence on cognition and blood indices, further studies will help venture more into this newer field of psycho endoneuroimmunology.

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Explicit memory in pregnant women

Cited by 91 publications

References 18 publications

Progesterone selectively increases amygdala reactivity in women

Progesterone selectively increases amygdala reactivity in women

Implicit memory varies across the menstrual cycle: estrogen effects in young women

Analysis of relationship between memory functions and blood indices across parturition in primigravidae

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