Exploitation of the Bulgarian Flora's Biodiversity as a Source of Immunomodulatory and/or Antineoplastic Agents: Current Challenges and Perspectives

Nikolov, S; Momekov, Georgi; Kitanov, G.; Йонкова, Илиана; Krasteva, Ilina; Toshkova, Reneta; Konstantinov, Spiro; Nedialkov, Paraskev; Karaivanova, Margarita

doi:10.1080/13102818.2007.10817497

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…euxinum (0.50–0.96 DW%), L. lewisii (0.16–0.30 DW%) and L. altaicum (0.92–0.96 DW%) has been reported [65]. Screening of Bulgarian flora in vitro cultures has shown numerous species, producing justicidin B [66]. Callus (light grown) and suspension cultures (dark grown) of L. narbonense accumulate 1.57 and 0.09 mg/g DW justicidin B [67,68].…”

Section: Production Of Justicidin B Using Biotechnologymentioning

confidence: 99%

Justicidin B: A Promising Bioactive Lignan

Hemmati

Seradj

2016

Molecules

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Adverse effects and drug resistance to the current onchopharmacologicals have increased the demand for alternative novel therapeutics. We herein introduce justicidin B, an arylnaphthalen lignan isolated from different plant origins, especially Justicia, Phyllanthus, Haplophyllum and Linum species. This cyclolignan exhibits a wide array of biological properties ranges from piscicidal to antifungal, antiviral and antibacterial activities. Activity against Trypanosoma brucei makes justicidin B a potential antiprotozoal agent for the treatment of neglected tropical diseases. Pharmacological properties like antiplatelet, anti-inflammatory and bone resorption inhibition have been also attributed to justicidin B. This compound is a potent cytotoxic substance on several cell lines, especially chronic myeloid and chronic lymphoid leukemia. Pharmacological values, natural variation, as well as biotechnological production of justicidin B by plant cell, tissue and organ culture are also described in this review. Chemical characteristics and chromatographic methods to identify justicidin B and its biosynthetic pathway have been discussed. Different approaches to the total synthesis of justicidin B are compared. This review would shed light on the role of justicidin B as an intriguing natural compound and provides a chance to optimize conditions for industrial applications.

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Section: Production Of Justicidin B Using Biotechnologymentioning

confidence: 99%

Justicidin B: A Promising Bioactive Lignan

Hemmati

Seradj

2016

Molecules

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“…Recently, Nikolov et al [20] have demonstrated the cytotoxic activity of extracts of Linum tauricum, L. leonii, and L. narbonense. These extracts contained high concentrations of other PTOX-like lignans, which could be a new source of precursors for the semi-synthesis of lignan-based drugs.…”

Section: Ptox and Its Derivativesmentioning

confidence: 99%

Podophyllotoxin: Current approaches to its biotechnological production and future challenges

Yousefzadi¹,

Sharifi²,

Behmanesh³

et al. 2010

Engineering in Life Sciences

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Many plant‐derived agents are being used to treat cancer, including taxol, vinblastine, vincristine, or camptothecin and podophyllotoxin derivatives, among others. Plant biotechnology can provide a new tool for the production of anticancer agents but in spite of considerable efforts to produce vinblastine and vincristine in cell cultures and knowledge of the biosynthetic pathway of Catharanthus roseus alkaloids, the biotechnological production of taxol has only been achieved at an industrial level by companies such as Phyton Biotech and Cytoclonal Pharmaceutics. Podophyllotoxin was isolated as the active antitumor agent from the roots of Podophyllum species and more recently from the genus Linum and others. Etoposide, teniposide, and etophos are semi‐synthetic derivatives of podophyllotoxin and are used in the treatment of cancer. Biotechnological approaches, including the use of cell cultures, biotransformation, or metabolic engineering techniques to manipulate the biosynthetic pathway, represent an alternative for the production of podophyllotoxin and are discussed in this review.

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“…Research showed that the main bioactive components were podophyllotoxin and its derivatives [2,3]. Podophyllotoxin exhibits significant biological activity such as anti-genital warts [4,5], anticancer activity [6] and immunomodulatory activity [7], and its semi-synthetic derivatives including etoposide, teniposide and etopophos are used as important chemotherapies of various cancers [8][9][10]. Further studies on pharmacological and clinical effects of podophyllotoxins necessitate the development of an efficient preparative separation method of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Zhu

et al. 2012

Journal of Chromatography B

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Exploitation of the Bulgarian Flora's Biodiversity as a Source of Immunomodulatory and/or Antineoplastic Agents: Current Challenges and Perspectives

Cited by 4 publications

References 30 publications

Justicidin B: A Promising Bioactive Lignan

Justicidin B: A Promising Bioactive Lignan

Podophyllotoxin: Current approaches to its biotechnological production and future challenges

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

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