Exploiting charge/ions compensating processes in PANI/SPANI/reduced graphene oxide composite for development of a high sensitive H2O2 sensor

Vilela, Edmilson Tinoco; Carvalho, Rita de Cássia Silva; Neto, Sakae Yotsumoto; Luz, Rita de Cássia Silva; Damos, Flávio Santos

doi:10.1016/j.jelechem.2015.06.009

Cited by 14 publications

(3 citation statements)

References 47 publications

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“…Graphene − and graphite , are also often employed for electrochemical applications due to their low residual current, readily renewable surface, and wide potential window. Carbon fibers have also attracted attention due to the fact that they have more edge sites on the outer wall than CNTs, which can facilitate the ET of electroactive analytes …”

Section: Technological Applications Of Cytochrome Cmentioning

confidence: 99%

Multifunctional Cytochrome c: Learning New Tricks from an Old Dog

et al. 2017

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Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure, particularly in the ferric form, such that it is able to sample a broad conformational space. Depending on the specific conditions, interactions, and cellular localization, different conformations may be stabilized, which differ in structure, redox properties, binding affinities, and enzymatic activity. The primary function is electron shuttling in oxidative phosphorylation, and is exerted by the so-called native cyt c in the intermembrane mitochondrial space of healthy cells. Under pro-apoptotic conditions, however, cyt c gains cardiolipin peroxidase activity, translocates into the cytosol to engage in the intrinsic apoptotic pathway, and enters the nucleus where it impedes nucleosome assembly. Other reported functions include cytosolic redox sensing and involvement in the mitochondrial oxidative folding machinery. Moreover, post-translational modifications such as nitration, phosphorylation, and sulfoxidation of specific amino acids induce alternative conformations with differential properties, at least in vitro. Similar structural and functional alterations are elicited by biologically significant electric fields and by naturally occurring mutations of human cyt c that, along with mutations at the level of the maturation system, are associated with specific diseases. Here, we summarize current knowledge and recent advances in understanding the different structural, dynamic, and thermodynamic factors that regulate the primary electron transfer function, as well as alternative functions and conformations of cyt c. Finally, we present recent technological applications of this moonlighting protein.

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Section: Technological Applications Of Cytochrome Cmentioning

confidence: 99%

Multifunctional Cytochrome c: Learning New Tricks from an Old Dog

et al. 2017

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“…Hydrogen peroxide, H 2 O 2 , is widely used in many fields such as clinical [ 190 ], industrial [ 191 ], and environmental analysis [ 192 ]; it is also a byproduct of several oxidative biological reactions. It is essential to determine H 2 O 2 concentration for studying different kinds of disorders in the human body such as cancer, Alzheimer’s, and Parkinson’s, as well as in various industrial applications [ 193 ].…”

Section: Electrochemical Sensors Based On Conducting Polymersmentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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Electrochemical sensors appear as low-cost, rapid, easy to use, and in situ devices for determination of diverse analytes in a liquid solution. In that context, conducting polymers are much-explored sensor building materials because of their semiconductivity, structural versatility, multiple synthetic pathways, and stability in environmental conditions. In this state-of-the-art review, synthetic processes, morphological characterization, and nanostructure formation are analyzed for relevant literature about electrochemical sensors based on conducting polymers for the determination of molecules that (i) have a fundamental role in the human body function regulation, and (ii) are considered as water emergent pollutants. Special focus is put on the different types of micro- and nanostructures generated for the polymer itself or the combination with different materials in a composite, and how the rough morphology of the conducting polymers based electrochemical sensors affect their limit of detection. Polypyrroles, polyanilines, and polythiophenes appear as the most recurrent conducting polymers for the construction of electrochemical sensors. These conducting polymers are usually built starting from bifunctional precursor monomers resulting in linear and branched polymer structures; however, opportunities for sensitivity enhancement in electrochemical sensors have been recently reported by using conjugated microporous polymers synthesized from multifunctional monomers.

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“…Nano-structuring of metal-grafted carbon nanostructures into conductive nanocomposites has provided high-caliber electrochemical sensors 23 . Graphene/polyaniline (PANI) nanocomposites with enhanced electrochemical properties and conductive characteristics have been developed for energy storage 24 , shielding of electromagnetic pollution 25 , electrocatalysis 26 and particularly biosensing 27–30 . Incorporation of metal-NPs have also enhanced the electrical conductivity of the graphene/PANI composites 31 .…”

Section: Introductionmentioning

confidence: 99%

Sandwich-structured nanoparticles-grafted functionalized graphene based 3D nanocomposites for high-performance biosensors to detect ascorbic acid biomolecule

Salahandish

Ghaffarinejad

Naghib

et al. 2019

Sci Rep

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We present a highly sensitive and selective nano-biosensor for rapid, stable and highly reproducible detection of ascorbic acid (AA) in the presence of dopamine, uric acid and other interferences by a three-layer sandwich arrangement of nitrogen-doped functionalized graphene (NFG), silver nanoparticles (AgNPs) and nanostructured polyaniline (PANI) nanocomposite. The enhanced AA electrochemical properties of the NFG/AgNPs/PANI electrode is attributed to the superior conductivity of the NFG-PANI and the excellent catalytic activity of AgNPs. The critical modification of the AgNPs-grafted NFG-PANI coated on very low-cost fluorine doped tin oxide electrode (FTOE) increased the charge transfer conductivity of the electrode (the resistance drops down from 11,000 Ω to 6 Ω). The nano-biosensor was used to accurately detect AA in vitamin C tablets with the recovery of 98%. The sensor demonstrated a low detection limit of 8 µM (S/N = 3) with a very wide linear detection range of 10–11,460 µM, good reproducibility and excellent selectivity performance for AA detection. The results demonstrate that this nanocomposite is a promising candidate for rapid and selective detection of AA in practical clinical samples.

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Exploiting charge/ions compensating processes in PANI/SPANI/reduced graphene oxide composite for development of a high sensitive H2O2 sensor

Cited by 14 publications

References 47 publications

Multifunctional Cytochrome c: Learning New Tricks from an Old Dog

Multifunctional Cytochrome c: Learning New Tricks from an Old Dog

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

Sandwich-structured nanoparticles-grafted functionalized graphene based 3D nanocomposites for high-performance biosensors to detect ascorbic acid biomolecule

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