Exploiting itraconazole-loaded nanomixed micelles in coated capsules as efficient colon-targeted delivery system for improved antifungal and potential anticancer efficacy

Adel, Shery; Fahmy, Rania Samir; Elsayed, Ibrahim; Mohamed, M. I.; Ibrahim, Reem R.

doi:10.1080/10837450.2023.2195486

Cited by 2 publications

(2 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hemolytic assay is a widely employed method for the characterization of biosurfactant biocompatibility, serving as the sole approach utilized for this purpose [15]. In order to assess the blood safety profile or hemocompatibility of the formulated substances, the impact of ITZ, SA and ITZ micelles formulations on the hemolysis of RBCs was examined subsequent to the incubation of micelles with blood.…”

Section: In Vitro Hemolysismentioning

confidence: 99%

See 1 more Smart Citation

Itraconazole Loaded Biosurfactin Micelles with Enhanced Antifungal Activity: Fabrication, Evaluation and Molecular Simulation

Usman,

Farooq,

Wani

et al. 2023

Antibiotics

View full text Add to dashboard Cite

Itraconazole (ITZ) is a broad-spectrum antifungal for superficial subcutaneous and systemic fungal infections. This study aimed to enhance the antifungal activity of ITZ using surfactin A (SA), a cyclic lipopeptide produced by the SA-producing Bacillus strain NH-100, possessing strong antifungal activity. SA was extracted, and ITZ-loaded SA micelles formulations were prepared via a single-pot rinsing method and characterized by particle size, zeta potential, and infrared spectroscopy. In vitro dissolution at pH 1.2, as well as hemolysis studies, was also carried out. The fabricated formulations were stable and non-spherical in shape, with an average size of about 179 nm, and FTIR spectra depicted no chemical interaction among formulation components. ITZ-loaded micelles showed decreased hemolysis activity in comparison to pure ITZ. The drug released followed the Korsmeyer–Peppas model, having R2 0.98 with the diffusion release mechanism. In an acidic buffer, drug release of all prepared formulations was in the range of 73–89% in 2 h. The molecular simulation showed the outstanding binding and stability profile of the ITZ-SA complex. The aromatic ring of the ITZ mediates a π-alkyl contact with a side chain in the SA. It can be concluded that ITZ-loaded micelles, owing to significant enhanced antifungal activity up to 6-fold due to the synergistic effect of SA, can be a promising drug delivery platform for delivery of poorly soluble ITZ.

show abstract

Section: In Vitro Hemolysismentioning

confidence: 99%

“…These micelles enclose the drug molecules, increasing their stability and solubility. The hydrophobic part of the micelle makes it easier to penetrate the fungal cell membranes, while the hydrophilic surface of the micelle interacts with the aqueous environment [15].…”

Section: Introductionmentioning

confidence: 99%