Exploiting Senescence for Cancer Treatment

Abstract

Senescence is considered as a cellular defensive response evoked by diverse stimuli to combat tumor development and progression. An evolving body of knowledge indicates that tumor cells are capable of undergoing senescence when latent senescence pathways are reengaged. Given the apparent benefits associated with senescence induction as a therapy outcome, targeting of senescence triggering factors is being actively pursued. In this review, we briefly describe modes of senescence induction and discuss therapy approaches being undertaken for the development of prosenescence anti-cancer therapies.