Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: Synergy between physical, chemical and biological approaches

Anselmo, Aaron C.; Kumar, Sunny; Gupta, Vivek; Pearce, Austin M.; Ragusa, Analisa; Muzykantov, Vladimir R.; Mitragotri, Samir

doi:10.1016/j.biomaterials.2015.07.043

Cited by 83 publications

(68 citation statements)

References 55 publications

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“…Recently, Blanco et al (15) emphasized the importance of these barriers for exploiting the clinical potential of NP-based drug delivery (15). In this regard, NP size and geometry play a major role in their biodistribution (16)(17)(18). The challenge of certain NP-delivered drugs to pass biological barriers associated with their opsonization and sequestration by monocytes limits their site-specific bioavailability.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Muñoz

Bilyy

Biermann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

133

118

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The critical size for strong interaction of hydrophobic particles with phospholipid bilayers has been predicted to be 10 nm. Because of the wide spreading of nonpolar nanoparticles (NPs) in the environment, we aimed to reveal the ability of living organisms to entrap NPs via formation of neutrophil extracellular traps (NETs). Upon interaction with various cell types and tissues, 10-to 40-nmsized NPs induce fast (<20 min) damage of plasma membranes and instability of the lysosomal compartment, leading to the immediate formation of NETs. In contrast, particles sized 100-1,000 nm behaved rather inertly. Resulting NET formation (NETosis) was accompanied by an inflammatory reaction intrinsically endowed with its own resolution, demonstrated in lungs and air pouches of mice. Persistence of small NPs in joints caused unremitting arthritis and bone remodeling. Small NPs coinjected with antigen exerted adjuvant-like activity. This report demonstrates a cellular mechanism that explains how small NPs activate the NETosis pathway and drive their entrapping and resolution of the initial inflammatory response.nanoparticles | size | neutrophils | NETosis | inflammation

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Section: Resultsmentioning

confidence: 99%

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Muñoz

Bilyy

Biermann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

133

118

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“…3c) [158]. In a follow-up study [159], lung accumulation and clearance organ avoidance of RBC-hitchhiked nanoparticles were improved further by leveraging the use of rod-shaped particles, which have recently been used for lung targeting [160]. Spherical and rod-shaped particles, RBC-hitchhiked and non-hitchhiked, were functionalized either with clearance organ targeting moiety, IgG, or with ICAM antibodies providing affinity to endothelium and directly compared for their liver, spleen, and lung uptake (Fig.…”

Section: Particles/carriers Designed For Targeting To or Carriage mentioning

confidence: 99%

“…4a). The formulation which provided the best lung targeting, while decreasing uptake in the liver and spleen, leveraged synergistic contributions from RBC-hitchhiking, lung-targeting antibodies, and rod-shaped nanoparticles [159]. …”

Section: Particles/carriers Designed For Targeting To or Carriage mentioning

confidence: 99%

“…(d) Hypotonic swelling and subsequent sealing of RBCs to include nanocarriers inside RBCs. (a) Reprinted from [159], Copyright (2015), with permission from Elsevier. (b) Adapted with permission from [149].…”

Section: Figmentioning

confidence: 99%

“…(d) Biotinylated RBCs with avidin-conjugated iron oxide nanoparticles used for enhanced magnetic targeting in a tumor model in mice. (a) Reprinted from [159], Copyright (2015), with permission from Elsevier. (b and c).…”

Section: Figmentioning

confidence: 99%

See 2 more Smart Citations

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

Villa

Anselmo

Mitragotri

et al. 2016

Advanced Drug Delivery Reviews

Self Cite

313

227

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Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for example, by changing margination within the intravascular space), and modulating immune responses to appended cargoes. Strategies for RBC drug delivery systems include internal and surface loading, and the latter can be performed both ex vivo and in vivo. A relatively new avenue for RBC drug delivery is their application as a carrier for nanoparticles. Efforts are also being made to incorporate features of RBCs in nanocarriers to mimic their most useful aspects, such as long circulation and stealth features. RBCs have also recently been explored as carriers for the delivery of antigens for modulation of immune response. Therefore, RBC-based drug delivery systems represent supercarriers for a diverse array of biomedical interventions, and this is reflected by several industrial and academic efforts that are poised to enter the clinical realm.

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Biodistribution of Polymeric, Polysaccharide and Metallic Nanoparticles

Erdoğar

Varan

et al. 2020

Characterization of Pharmaceutical Nano and Microsystems

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Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: Synergy between physical, chemical and biological approaches

Cited by 83 publications

References 55 publications

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

Biodistribution of Polymeric, Polysaccharide and Metallic Nanoparticles

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