Exploiting the inductive effect of the trifluoromethyl group: regioselective gold-catalyzed hydration of 2,2,2-trifluoroethyl-substituted alkynes

Abstract

The strong directing effect of the trifluoromethyl group is illustrated in the Au-catalyzed hydration reaction of 2,2,2-trifluoroethyl-substituted alkynes which produces β-trifluoromethylketones as the major products.