2012
DOI: 10.2174/092986712800784711
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Exploiting the Properties of Biomolecules for Brain Targeting of Nanoparticulate Systems

Abstract: The main obstacle in the treatment of central nervous system diseases is represented by a limited passage of diagnostic and therapeutic agents across the blood-brain barrier, which separates the blood stream from the cerebral parenchyma and maintains the homeostasis of the brain. The growing knowledge about the brain capillary endothelium and the discovery of specific mechanisms for the uptake of substances enables the development of various strategies to enhance the drug delivery rate into the brain. Among th… Show more

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Cited by 10 publications
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“…Nanotechnologies have largely been reported to be able to cargo small molecules or oligonucleotides into the brain if they are targeted to the brain by specific ligands [ 57 ] but examples with antibodies are rare. The concept has been specifically applied to an anti-Aβ amyloid VHH after encapsulation in liposomes decorated with glutathione (GSH) [ 58 ].…”
Section: Single-domain Antibodies Crossing the Blood–brain Barriermentioning
confidence: 99%
“…Nanotechnologies have largely been reported to be able to cargo small molecules or oligonucleotides into the brain if they are targeted to the brain by specific ligands [ 57 ] but examples with antibodies are rare. The concept has been specifically applied to an anti-Aβ amyloid VHH after encapsulation in liposomes decorated with glutathione (GSH) [ 58 ].…”
Section: Single-domain Antibodies Crossing the Blood–brain Barriermentioning
confidence: 99%