Exploration and analysis of flavonoid melanin inhibitors

Abstract

Melanin, a biological pigment produced by melanocytes through complex processes, exists widely in organisms and plays many positive roles. For example, ultraviolet radiation and harm from various external pollutants are prevented by melanin, which absorbs light to protect skin cells in human skin. With the increasing market demand for melanin inhibitors, a variety of small molecular compounds with different structures have been found to have the activity of inhibiting melanin synthesis. However, excessive synthesis of melanin can lead to serious skin diseases, of which the most widespread and representative is skin pigmentation. In this work, we analyzed the mechanism of melanin formation and found that tyrosinase plays a decisive role in melanin production, so tyrosinase inhibitors can effectively improve this kind of skin disease. At the same time, as flavonoids and dihydrochalcone derivatives were found to be representative tyrosinase inhibitors, the structure and structure-activity relationship of these compounds were summarized and analyzed. to explore the possible optimal conformation for the development of potential therapies for melanin-related dermatoses.