Exploration and characterization of a novel cocrystal hydrate consisting of captopril, an amino acid-derived drug

Abstract

We found a novel cocrystal consisting of captopril, which is an amino acid-derived drug having a thiol group, and l-proline by using nano-spot-screening with LF-Raman. This cocrystal hydrate showed high hygroscopicity resulted from changes in intermolecular interactions.