Exploration into practical significance of integral water permeability of textile vascular grafts

Guan, Guoping; Yu, Chenglong; Fang, Xuan; Guidoin, Robert; King, Martin W.; Wang, Hongjun; Wang, Lu

doi:10.1177/22808000211014007

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Guan et al [ 31 ] have analyzed vascular prosthesis permeability for water, plasma, and whole human blood. Woven grafts with a plain weave (monofilament in the warp and polyfilament in the weft) differing in the number of weft threads were investigated.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Weaving Technologies on the Integral Characteristics of Synthetic Vascular Prostheses

Shadanov¹,

Timchenko²,

Vladimirov³

et al. 2022

Sovrem Tehnol Med

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The aim of the study is to determine physical and structural properties of woven synthetic prostheses depending on the type of the weave.Materials and Methods. Ten vascular prostheses manufactured at the Science and Technology Park of the BNTU "Polytechnic" (Minsk, Republic of Belarus) have been analyzed. The prostheses differed in the type of weaving, duration and temperature of thermal fixation during crimping. Three samples had a single-layer structure and 7 samples had a double-layer structure. Tests for water permeability, resistance to radial bending, and porosity of the prostheses have been performed.Results. The single-layer woven prostheses have demonstrated a low level of water permeability: the best result was shown by sample No.1: 80 [77.1; 80.5] ml/min/cm 2 . A strong direct correlation was revealed for these prostheses: the larger the pore diameter, the greater permeability (r=0.778; p=0.05). The single-layer woven prostheses appeared to be most resistant to radial bending, samples No.1 and 3 had no deformations at the minimum radius of the cylinder (R<4 mm), sample No.2 showed deformation on the cylinder with R=5 mm. For the single-layer prostheses, a strong negative correlation was noted (r=-0.97; p=0.04) between the density of the warp threads and the kinking radius.All double-layer prostheses have demonstrated higher water permeability and weak resistance to deformation during radial bending. Samples No.4 and 8 were found to have minimum and maximum water permeability of 276.5 [258.3; 288.4] and 538.8 [533.3; 564.3] ml/min/cm 2 , respectively. The minimum kinking radius (7 mm) was shown by samples No.9 and 10. The worst results were demonstrated by sample No.6, which was deformed with minimal bending.Conclusion. Samples with ordinary plain weave have a low level of water permeability and high resistance to radial deformation, which makes them look most promising for the application in vascular surgery.

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Section: Discussionmentioning

confidence: 99%

The Influence of Weaving Technologies on the Integral Characteristics of Synthetic Vascular Prostheses

Shadanov¹,

Timchenko²,

Vladimirov³

et al. 2022

Sovrem Tehnol Med

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“…The suture strength was measured with a 2-0 braided polyester suture (Jinhuan Medical Supplies Co. Ltd, Shanghai, China). 33 The suture passed through one end of each specimen at 5 mm away from the edge. The suture was then pulled up at a speed of 5 mm/min until it detached from the specimen.…”

Section: Biomechanical Propertiesmentioning

confidence: 99%

Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair

Cheng

Xi³

et al. 2022

J Biomedical Materials Res

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Naringin (Nar), a natural flavanone glycoside, has been shown to possess a variety of biological activities, including anti-inflammatory, anti-apoptotic, bone formation, and so forth. In this study, Nar was oxidized by sodium periodate and the oxidized naringin (ONar) was used as a novel biological crosslinking agent. In addition, ONar-fixed porcine decellularized Achilles tendon (DAT) was developed to substitute anterior cruciate ligament (ACL) for researching a novel ACL replacement material. The ONar with a 24 h oxidation time had appropriate aldehyde group content, almost no cytotoxicity,

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“…Исследование текстильных ПКС из полиэтилентерефталата показало, что для размера пор (от 20 до 100 мкм) существует положительная корреляция (R 2 > 0,9) между водопроницаемостью и кровопотерей, но потери крови примерно в 10 раз меньше, чем проницаемость по воде [6], что объясняется более высокой вязкостью плазмы крови и присутствием в ней форменных элементов.…”

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Technique for reducing the surgical porosity of small-diameter vascular grafts

Nemets,

Khairullina,

Belov

et al. 2023

RJTAO

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High surgical porosity (SP) is one of the causes of significant blood loss, as well as hematoma formation. So, reducing the SP of small-diameter vascular grafts (VGs) is a crucial task.The objective of this work was to develop a technology for the formation of polycaprolactone (PCL)-based small-diameter VGs with a bioactive coating with reduced SP.Materials and methods. Porous VGs with an inner diameter of 3 mm were fabricated by electrospinning from 5% PCL solution with addition of 5–30% gelatin (PCL/G) on an NANON-01A unit (MECC CO, Japan). Bioactive coating was applied by sequential incubation of VGs in solutions of bovine serum albumin, heparin and platelet lysate with fixation in a glutaric aldehyde solution. The surface structure and mechanical properties of the samples were investigated. Functional properties of the bioactive VGs were evaluated in relation to their interaction with cell cultures in vitro.Results. It was found that introduction of gelatin into the working solution reduces SP from 30.4 ± 1.5 mL/(cm2 ·min) to 2.8 ± 0.5 ml/(cm2 ·min). It was shown that at a PCL/gelatin ratio of 9 : 1, the outer and inner sides of the bioactive VGs samples are characterized by surface uniformity (no defects), mechanical properties close to blood vessels of the same diameter (Young’s modulus 6.7 ± 2.1 MPa, tensile strength 26.7 ± 4.9 N and elongation to break 423 ± 80%) and ability to support adhesion and proliferation of human umbilical vein endothelial cell line, EA.hy926.Conclusion. Introduction of 10% gelatin content (by the polymer weight) into PCL solution reduces the SP of small-diameter VGs, leads to uniformity in their inner and outer surface, improvement in their mechanical properties without reducing their ability to support adhesion and proliferation of vascular endothelial cells.

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Exploration into practical significance of integral water permeability of textile vascular grafts

Cited by 5 publications

References 30 publications

The Influence of Weaving Technologies on the Integral Characteristics of Synthetic Vascular Prostheses

The Influence of Weaving Technologies on the Integral Characteristics of Synthetic Vascular Prostheses

Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair

Technique for reducing the surgical porosity of small-diameter vascular grafts

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