Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia via dynamic regional homogeneity analysis

Abstract

AimPatients with high myopia (HM) reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls (HCs) via dynamic regional homogeneity (dReHo) analysis.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined via correlation analysis.ResultsIn the left fusiform gyrus (L-FG), right inferior temporal gyrus (R-ITG), right Rolandic operculum (R-ROL), right postcentral gyrus (R-PoCG), and right precentral gyrus (R-PreCG), dReHo values were significantly greater in patients with HM than in HCs.ConclusionPatients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM.

Exploration of static functional connectivity and dynamic functional connectivity alterations in the primary visual cortex among patients with high myopia via seed-based functional connectivity analysis

“… Huang et al (2018a) revealed that the whole-brain gray matter volume of the right cuneus gyrus was decreased in patients with HM, indicating potential visual cortex functional impairment. Our previous study demonstrated that HM patients had altered dynamic regional homogeneity values in the left fusiform gyrus, right inferior temporal gyrus, right Rolandic operculum, right postcentral gyrus, and right precentral gyrus ( Ji et al, 2022 ). Thus far, research has mainly focused on changes in static brain activity in HM patients; and it is believed that the functional interaction of brain regions remains unchanged in time during the whole MRI scan, which is obviously not objective.…”

Altered Whole Brain Gray Matter Volume in High Myopia Patients - A Narrative Review

“…One of the common causes of vision impairment in the world is myopia. Myopia is alarmingly on the rise which negatively affects both the economic well-being of nations and the quality of life around the globe mainly due to high academic pressure and indoor time spent [1,2,3]. The high prevalence of myopia leads to an increased incidence of high myopia as these two are closely related diseases [3].…”

“…Myopia is alarmingly on the rise which negatively affects both the economic well-being of nations and the quality of life around the globe mainly due to high academic pressure and indoor time spent [1,2,3]. The high prevalence of myopia leads to an increased incidence of high myopia as these two are closely related diseases [3]. and ischemia, choroidal neovascularization, macular changes and hemorrhage, and myopic foveoschisis [3,4].…”

“…The high prevalence of myopia leads to an increased incidence of high myopia as these two are closely related diseases [3]. and ischemia, choroidal neovascularization, macular changes and hemorrhage, and myopic foveoschisis [3,4]. High myopia is a multifactorial medical condition but taking genetic profile into consideration, a number of genes have been identified to have a prominent role in the prognosis and progression of high myopia with diverse inheritance patterns [5].…”

“…Following changes in the axial length of the eye, the retina nerve fibres thin, and the optic disk deforms [1]. With very close relations between eye structures, optic nerves, and brain visualrelated areas, abnormal visual function leads to changes in the functional connectivity and morphology of the brain [1,3]. There are some methods such as Functional magnetic resonance imaging (fMRI), Voxel-Mirrored Homotopic Connectivity (VMHC), Regional homogeneity, and dynamic amplitude of low-frequency fluctuation to evaluate functional connectivity density and spontaneous neuronal activity in a resting state brain and recent studies show changed activities and impaired cognition in patients with high myopia [1,3].…”