Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects

Sisodiya, Shailendra; Paul, Subarno; Chaudhary, H; Grewal, Preeti; Kumar, Gulshan; Daniel, Divine P; Das, Biswajit; Nayak, Deepika; Guchhait, Sankar K.; Kundu, Chanakya Nath; Banerjee, Uttam Chand

doi:10.1016/j.bmcl.2021.128274

Cited by 13 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To calculate the apoptotic cells percentage after treatment with respective compounds, 4′,6-diamidino-2-phenylindole (DAPI) nuclear staining assay was carried out according to the previously describe protocol. 60 In brief, 70–80% cells (MCF-7) were treated with most potent compounds such as 10e and 10q for 48 h. Next, following a 1× PBS wash, the cells were fixed for 15 min at 20 °C in the dark using acetone : methanol (1 : 1). Then the fixed cells were first washed with 1× PBS, then DAPI solution was added, and the cells were then incubated for 1 h at 37 °C in the dark.…”

Section: Methodsmentioning

confidence: 99%

“…2.2.3 Compounds increase the apoptotic nuclei in cancer cells. The apoptotic potential of compounds 10e and 10q were analysed by DAPI nuclear staining assay 60 after treatment of MCF-7 cells with compound of varied concentrations for 48 h. Treatments were carried out by following concentrations of 0.5, 1.0, and 2.0 μM for 10e and 0.5, 0.8, and 2.0 μM for 10q exposure conditions with respect to control. It was observed that both the compounds with increasing concentrations showed higher shrinkage and deformation of nuclei, as compared to the control (Fig.…”

Section: Structure-activity Relationship Studies (Sar)mentioning

confidence: 99%

See 1 more Smart Citation

Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents

Krishna Rao,

Paul,

Gulkis

et al. 2024

RSC Med. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Structure-activity Relationship Studies (Sar)mentioning

confidence: 99%

Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents

Krishna Rao,

Paul,

Gulkis

et al. 2024

RSC Med. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“… Step 1: Juglone was prepared according to a literature report . CuCl (1.98 g, 20 mmol, 1equiv) was added to a room temperature MeCN (100 mL) solution of dihydroxynaphthalene (3.2 g, 20 mmol, 1 equiv) under an O 2 atmosphere.…”

Section: Methodsmentioning

confidence: 99%

Copper(I)-Mediated Divergent Synthesis of Pyrroquinone Derivatives and 2-Halo-3-amino-1,4-quinones

Wang

et al. 2023

J. Org. Chem.

View full text Add to dashboard Cite

A divergent transformation of 2-amino-1,4-quinones for the synthesis of pyrroquinone derivatives and 2-halo-3-amino-1,4-quinones was disclosed. The mechanistic study showed that both the tandem cyclization and halogenation involved a Cu(I)-catalyzed oxidative radical process. This protocol not only constructed a series of novel pyrroquinone derivatives with high atom economy but also provided a new method of halogenation via directed C(sp2)–H functionalization with CuX (X = I, Br, Cl) serving as the X (X = I, Br, Cl) source.

show abstract

“…Moreover, the cytotoxicity of synthesized compounds were evaluated against breast cancer cells (MCF-7 and MDA-MB-23), human embryonic kidney cells (HEK293T) and oral squamous cancer cells (H-357). Among them, compound 24c showed highest MCF-7, MDA-MB-23, and HEK293T cell inhibition with IC 50 values of 3.0 μΜ, 3.2 μΜ, and 4.0 μΜ respectively [109] (Figure 28). hypnotic, sedative, anticonvulsant, antibacterial, anesthetic, anticancer, and antitumor characteristics.…”

Section: Quinonesmentioning

confidence: 99%

Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates

Sahu

Chaurasiya

Chawla

2022

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

Cancer is a broad word for a set of diseases that can begin in virtually any organ or tissue of the body and spread to other organs. In 2020, cancer was the largest cause of death worldwide, accounting for 10 million fatalities, or one in every six deaths. Nitrogen containing heterocyclic compounds are a massive research focus because it has a unique position and is a cherished source of a wide range of bioactive molecules in medicinal chemistry. Over 75% of the currently accessible market is covered by FDA-approved drugs containing nitrogen moieties. DNA topoisomerase II is a reassuring approach for novel anticancer heterocyclic medicines because it plays a crucial role in DNA metabolism, replication, recombination, and repair. Given the importance of topo II in chemotherapy, there is a pressing necessity to boost topo II or multitarget topo II inhibitors in order to combat drug resistance and minimize toxicity. Following the trend of researching the advancement of effective topo II inhibitors with minimal toxicity, the current review article consolidates a detailed account of nitrogen-containing heterocyclic compounds and categorizes them into different classes based on structural characterization, such

show abstract

Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects

Cited by 13 publications

References 19 publications

Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents

Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents

Copper(I)-Mediated Divergent Synthesis of Pyrroquinone Derivatives and 2-Halo-3-amino-1,4-quinones

Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates

Contact Info

Product

Resources

About