Exploration of Central Kalimantanâ€™s forest plants as bioactive compound resources

Wahyuningsih, Mae Sri Hartati; Wahyuono, Subagus; Santosa, Djoko; Setiadi, Jusain; Soekotjo, Soekotjo; Widiastuti, Siti . Muslimah; Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum

doi:10.13057/biodiv/d090303

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a source phytopharmaca or modern medicine [7]. Opportunity exploration of medicinal plants is still very wide open in line with the development of herbal industry, herbal medicine, and phytopharmaca.…”

Section: Introductionmentioning

confidence: 99%

“…Natural resources provide a huge and highly diversified chemical bank from which we can explore for potential therapeutic agents by bioactivity-targeted screenings [ 6 ]. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a source phytopharmaca or modern medicine [ 7 ]. Opportunity exploration of medicinal plants is still very wide open in line with the development of herbal industry, herbal medicine, and phytopharmaca.…”

Section: Introductionmentioning

confidence: 99%

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Screening ofα-Glucosidase Inhibitory Activity from Some Plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae

Elya

Basah²,

Mun’im³

et al. 2012

Journal of Biomedicine and Biotechnology

135

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Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2 DM is more common in diabetic populations. In this type of DM, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the α-glucosidase inhibitor. In this study, we determine the α-glucosidase inhibitory activity of 80% ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the α-glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC50 117.20 μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC50 values in the range 2.33–112.02 μg/mL.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening ofα-Glucosidase Inhibitory Activity from Some Plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae

Elya

Basah²,

Mun’im³

et al. 2012

Journal of Biomedicine and Biotechnology

135

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“…Alkaloid dari batang dan akar tumbuhan sekunyit tersebut berjenis sama. Selain itu, sekunyit juga diketahui mengandung senyawa terpenoid, baik pada batang, daun maupun akarnya (8).…”

Section: Familiunclassified

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI DARI AKAR DAN BATANG TUMBUHAN SEKUNYIT (Fibraurea tinctoria Lour)

Utami

Winarsih

Fernando

et al. 2020

JFI

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Sekunyit (Fibraurea tinctoria Lour) merupakan tumbuhan yang berbentuk liana yang akar dan batangnya digunakan secara tradisional sebagai obat, salah satunya digunakan sebagai obat diare. Penelitian ini dilakukan untuk mengetahui aktivitas antibakteri ekstrak dan fraksinya terhadap bakteri penyebab diare meliputi Escherichia coli, Salmonella typhii, Staphylococcus aureus dan Vibrio cholerae. Sampel akar dan batang dimaserasi dengan etanol dan selanjutnya diultrasonikasi selama 30 menit. Fraksinasi dilakukan menggunakan metode asam basa dengan pelarut n-heksana, kloroform dan butanol. Ekstrak dan fraksi kemudian diuji aktivitas antibakterinya menggunakan metode difusi agar pada konsentrasi 30; 15; 7,5; 3,75 dan 1,88%. Hasil uji menunjukkan bahwa ekstrak etanol, fraksi n-heksana, fraksi kloroform A dan fraksi kloroform B dari akar dan batang sekunyit memberikan aktivitas antibakteri terhadap semua bakteri uji dengan kategori lemah sampai sedang, sedangkan fraksi butanol tidak memberikan hambatan, baik terhadap bakteri Escherichia coli, Salmonella typhii, Staphylococcus aureus maupun Vibrio cholerae.

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“…Uji toksisitas yang demikian dapat digunakan sebagi skrining awal terhadap senyawa aktif yang diduga berkhasiat sebagai antitumor. Skrining yang menggunakan BSLT seringkali mempunyai korelasi positif dengan potensinya sebagai antikanker (Anderson, 1991;Wahyuningsih, et al, 2008).…”

Section: Hasil Dan Pembahasanunclassified

Uji Toksisitas Senyawa Bioaktif Tumbuhan Polohi Wasu (Begonia sp.) terhadap Larva Udang (Artemia salina Leach)

2015

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Jurusan Farmasi, Fakultas Farmasi Universitas Tujuh Belas Agustus 1945, Jakarta. ABSTRAKTumbuhan Polohi Wasu (Begonia sp.) telah diuji toksisitasnya terhadap Larva Udang (Artemia salina Leach)". Penelitian ini bertujuan untuk mengetahui toksisitas senyawa bioaktif yang terkandung dalam tumbuhan yang digunakan sebagai obat tradisional. Ekstraksi dilakukan dengan menggunakan beberapa jenis pelarut yaitu: metanol, n-heksan; etilasetat dan air. Uji toksisitas senyawa aktif terhadap larva udang menggunakan metode Brine Shrimp Lethality Test (BSLT). Variasi konsentrasi larutan uji adalah 1000 ppm, 800 ppm, 600 ppm, 400 ppm, 200 ppm dan 100 ppm. Persentasi kematian larva udang dihitung setelah pengamatan 24 jam, menggunakan persamaan McLaughlin sehingga dapat diketahui nilai LC50 dari sampel yang diuji. Hasil penelitian menunjukkan bahwa ekstrak metanol dengan LC50 sebesar 369 ppm, fraksi n-heksan dengan LC50 sebesar 665 ppm, fraksi etilasetat dengan LC50 sebesar 433 ppm dan fraksi air dengan LC50 sebesar 419 ppm. Dengan demikian dapat dikatakan bahwa polohi wasu merupakan tumbuhan yang memiliki efek toksik sehingga berpotensi sebagai senyawa bioaktif.Kata Kunci: Toksisitas senyawa bioaktif, Begonia sp, Larva Udang (Artemia salina Leach) ABSTRACTPolohi Wasu (Begonia sp.) plant have been researched its toxicity to Artemia salina Leach. The aim of this research is to find toxicity in bioactive compounds of plant which have been used as traditional medicine. Extraction conducted by using some kind of solvent such as methanol extract, hexane fraction; ethylacetate and water fraction. The toxicity test of bioactive compound to Artemia salina using Brine Shrimp Lethality Test (BSLT) method. Variation Concentration in solution is 1000 ppm, 800 ppm, 600 ppm, 400 ppm, 200 ppm and 100 ppm. Mortality percentage of brine shrimp counted after 24 hour observation, using McLaughlin equation, so we can determine value of LC50 from research sample. The result of research show that methanol extract with LC50 at 369 ppm, Hexane fraction with LC50 at 665 ppm, ethylacetate fraction with LC50 at 433 ppm and water fraction with LC50 at 419 ppm. So we can concluded that polohi wasu plant with toxic efect and have potential as bioactive compounds.

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Exploration of Central Kalimantanâ€™s forest plants as bioactive compound resources

Cited by 5 publications

References 5 publications

Screening ofα-Glucosidase Inhibitory Activity from Some Plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae

Screening ofα-Glucosidase Inhibitory Activity from Some Plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI DARI AKAR DAN BATANG TUMBUHAN SEKUNYIT (Fibraurea tinctoria Lour)

Uji Toksisitas Senyawa Bioaktif Tumbuhan Polohi Wasu (Begonia sp.) terhadap Larva Udang (Artemia salina Leach)

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