Exploration of endoscopic findings and risk factors of early gastric cancer after eradication of <i>Helicobacter pylori</i>

Yan, Xiaohan; Hu, Xiao; Duan, Bensong; Pan, Jie; Fu, Jindong; Xu, Meiqing; Xu, Qinwei

doi:10.1080/00365521.2020.1868567

Cited by 10 publications

(8 citation statements)

References 29 publications

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“…27 Shibukawa et al and Yan et al both reported that GX was a risk factor for early gastric cancer after H. pylori eradication. 28,29 And Kitamura et al found that GX was strongly correlated with the differentiation of gastric cancer. 30 Xiao et al found that the incidence of gastric atrophy and intestinal metaplasia was significantly higher in patients with GX than in those without GX and that age and intestinal malformation were independently associated with GX.…”

Section: Discussionmentioning

confidence: 99%

“…Yamashita et al revealed that the detection rate of GX was significantly higher in patients with gastric cancer than in those without, and further multifactorial analysis showed that GX was an independent risk factor for gastric cancer 27 . Shibukawa et al and Yan et al both reported that GX was a risk factor for early gastric cancer after H. pylori eradication 28,29 . And Kitamura et al found that GX was strongly correlated with the differentiation of gastric cancer 30 .…”

Section: Discussionmentioning

confidence: 99%

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Relationship between gastric xanthoma, gastric precancerous lesions, and gastric cancer: A retrospective study

Shen

Chen

et al. 2023

J of Digest Diseases

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ObjectiveTo evaluate the relationship between gastric cancer and its precancerous lesions and gastric xanthoma.MethodsMedical records of 47 736 patients who underwent gastroscopy in our center from January 2020 to December 2021 were reviewed. Patients’ age, sex, endoscopic and histopathological findings, and the presence, number and location of gastric xanthoma were recorded. To investigate the detection rate of gastric xanthoma at different stages of gastric lesions, the participants were further divided into the chronic gastritis group (n = 42 758), the precancerous lesion group (n = 3672), and the gastric cancer group (n = 1306), respectively.ResultsThe overall detection rate of gastric xanthoma was 2.85%, and it was most commonly observed in the gastric antrum (52.50%). In addition, gastric xanthoma was more common in men and more likely to be single lesion. It was most detected in the precancerous lesion group (8.39%), followed by the gastric cancer group (5.44%), and least in the chronic gastritis group (2.29%). Multivariate analysis showed that gastric xanthoma was closely related to precancerous lesions (odds ratio [OR] 3.197, 95% confidence interval [CI] 2.791–3.662, P < 0.001) and gastric cancer (OR 1.794, 95% CI 1.394–2.309, P < 0.001).ConclusionGastric xanthoma is closely related to gastric precancerous lesions and gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between gastric xanthoma, gastric precancerous lesions, and gastric cancer: A retrospective study

Shen

Chen

et al. 2023

J of Digest Diseases

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“…Therefore, speed of gastric cancer growth may be unrelated to active H. pylori infection. Recent studies have shown that map-like redness represents a risk factor for the development of gastric cancer after successful eradication of H. pylori [ 21 , 22 ]. However, besides xanthoma, these endoscopic characteristics were not associated with the speed of gastric cancer growth in the present study.…”

Section: Discussionmentioning

confidence: 99%

Gastric Xanthoma Is Related to the Rapid Growth of Gastric Cancer

Miura

Oshima

Tamura

et al. 2021

JCM

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Early detection of gastric cancer is important. However, rapid growth of gastric cancers that cannot be resected endoscopically occurs even with periodic check-ups. Accordingly, we assessed factors associated with the speed of gastric cancer growth by examining historical endoscopic images. A total of 1996 gastric cancer cases were screened, and characteristics of lesions with slow and rapid growth were assessed. A total of 114 lesions from 114 patients were included in the assessment. Sixty slow-growing and fifty-four rapidly growing gastric cancers were compared. Female sex and incidence of lesions in the lower part of the stomach were significantly less frequent in the rapid-growth group than in the slow-growth group. History of endoscopic treatment tended to be more frequent in the rapid-growth group. Age, body mass index, histology, Helicobacter pylori status, and medications did not differ significantly between groups. Xanthoma was significantly related to rapid growth of gastric cancer, and map-like redness tended to be more frequent in the rapid-growth group in univariate analysis. Xanthoma was significantly related to rapid growth of gastric cancer on multivariate analysis. Further studies are warranted to clarify the pathophysiological mechanisms involved in the speed of gastric cancer growth.

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“…Table 5 shows the risk of GC following H. pylori eradication. A Kyoto atrophy score of 2 and MLR are both indicators of GC after eradication, with ORs of 8.1 and 1.8-5.3, respectively[ 55 - 57 ]. Additionally, RAC was inversely associated with eradicated GC (ORs = 0.3-0.4)[ 56 , 58 ].…”

Section: Gc Risk Of Kyoto Classificationmentioning

confidence: 99%

“…In Western countries, RAC and endoscopic IM have been extensively studied; however, other endoscopic findings, such as atrophy, EF, nodularity, DR, and MLR, have been less extensively explored, and further studies in more varied populations are required. This article does not mention a variety of important endoscopic findings, including spotty redness as a predictor of H. pylori infection[ 62 ]; xanthoma[ 57 , 63 , 64 ], foveolar hyperplastic polyp[ 65 ], refluxed bile[ 66 ], and a lack of fundic gland polyp[ 64 ] to predict GC; and depressive erosion and fundic gland polyp as indicators of functional dyspepsia[ 32 , 67 ]. Further research is required to confirm these findings.…”

Section: Future Perspectives In Kyoto Cassificationmentioning

confidence: 99%

Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis

Toyoshima¹,

Nishizawa²

2022

World J Gastroenterol

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This editorial provides an update of the recent evidence on the endoscopy-based Kyoto classification of gastritis, clarifying the shortcomings of the Kyoto classification, and providing prospects for future research, with particular focus on the histological subtypes of gastric cancer (GC) and Helicobacter pylori ( H. pylori ) infection status. The total Kyoto score is designed to express GC risk on a score ranging from 0 to 8, based on the following five endoscopic findings: Atrophy, intestinal metaplasia (IM), enlarged folds (EF), nodularity, and diffuse redness (DR). The total Kyoto score reflects H. pylori status as follows: 0, ≥ 2, and ≥ 4 indicate a normal stomach, H. pylori -infected gastritis, and gastritis at risk for GC, respectively. Regular arrangement of collecting venules (RAC) predicts non-infection; EF, nodularity, and DR predict current infection; map-like redness (MLR) predicts past infection; and atrophy and IM predict current or past infection. Atrophy, IM, and EF all increase the incidence of H. pylori -infected GC. MLR is a specific risk factor for H. pylori -eradicated GC, while RAC results in less GC. Diffuse-type GC can be induced by active inflammation, which presents as EF, nodularity, and atrophy on endoscopy, as well as neutrophil and mononuclear cell infiltration on histology. In contrast, intestinal-type GC develops via atrophy and IM, and is consistent between endoscopy and histology. However, this GC risk-scoring design needs to be improved.

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Exploration of endoscopic findings and risk factors of early gastric cancer after eradication of Helicobacter pylori

Cited by 10 publications

References 29 publications

Relationship between gastric xanthoma, gastric precancerous lesions, and gastric cancer: A retrospective study

Relationship between gastric xanthoma, gastric precancerous lesions, and gastric cancer: A retrospective study

Gastric Xanthoma Is Related to the Rapid Growth of Gastric Cancer

Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis

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