Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites

Abstract

Nature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has gradually become more challenging, and advances in novel strategic approaches are essential to evolve natural product chemistry. Our focus has been on surveying untouched marine resources and fermentation to enhance microbial productive performance. The first topic is the screening of marine natural products isolated from Indonesian marine organisms for new types of bioactive compounds, such as antineoplastics, antimycobacterium substances, and inhibitors of protein tyrosine phosphatase 1B, sterol O-acyl-transferase, and bone morphogenetic protein-induced osteoblastic differentiation. The unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented. This review presents an overview of our recent work accomplishments based on the MONOTORI study. Graphic abstract

Indonesian marine and its medicinal contribution

“…Marine microorganisms are possibly the next bio-manufacturer of diverse bioactive compounds in addition to terrestrial plants and nonmarine microorganisms [ 14 , 136 ]. Other than eight clinically approved marine-derived natural products on the market [ 13 ], more than twenty more marine natural products and derivatives have advanced to clinical trials, including plinabulin, lurbinectedin, tetrodotoxin, salinosporamide A, and depatuxizumab mafodotin [ 136 ].…”

“…The archipelago of Indonesia is home to a highly broad variety of marine bacteria [ 12 , 14 ] with examples exhibiting bioactivity tabulated in Additional file 1 : Table S7. Compared to micro fungi studies, there are a lesser number of secondary metabolites extracted from Indonesian marine bacteria.…”

“…There are few published reviews on Indonesian marine natural products with one only reporting on marine invertebrates, sponges, tunicate and soft corals collected from 2007 to 2020 [ 12 ], with another covering a limited dataset curated from 1970 to 2017 which includes marine natural products distributed across 94 species [ 13 ], while another discusses only marine organohalogen compounds [ 14 ]. All these manuscripts offer limited and specific commentary and fail to provide a broad and comprehensive perspective of the Indonesian marine phytochemistry environment.…”

Antimicrobial and quorum sensing inhibitory activity of epiphytic bacteria isolated from the red alga Halymenia durvillei

“…The search for novel bioactive compounds in developing new drugs has prompted the exploration of underutilized resources in various ecosystems and environmental conditions [ 1 ]. Marine microbes, for example, have gained the attention of many researchers due to the chemical and structural diversity of the metabolites they produce and the various modes of action they exhibit [ 2 ].…”