Exploration of metabolomics of Phyllanthus emblica: From ayurveda food to modern prospectives in quality control

Ruhela, Grishm; Dhama, Pooja; Shanker, Karuna; Ding, Xianting; Sharma, Alok

doi:10.1016/j.focha.2023.100330

Cited by 2 publications

(1 citation statement)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quercetin Quercetin (QC) is a flavonoid derived from plants and is present in fruits and vegetables in high amounts [97]. One of the most important medicinal properties of QC is its anticancer activity [98].…”

Section: Nanoformulations Applications Referencementioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One of the most significant barriers that medications must overcome to exert a therapeutic effect is the impact of the first hepatic transit. Studies have shown that controlled-release systems using nanoparticles composed of biodegradable natural polymers significantly improve oral administration, which is why these materials have attracted significant attention. Chitosan possesses a wide variety of properties and functions in the pharmaceutical as well as healthcare industries. Drug encapsulation and transport within the body are two of its most important features. Moreover, chitosan can enhance drug efficacy by facilitating drug interaction with target cells. Based on its physicochemical properties, chitosan can potentially be synthesized into nanoparticles, and this review summarizes recent advances and applications of orally delivered chitosan nanoparticle interventions.

show abstract

Section: Nanoformulations Applications Referencementioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

DietaryPhyllanthus emblica L.(Indian gooseberry, Amla) improves fecundity and resistance to oxidative stress in aDrosophila melanogastermodel of early-life malnutrition

Padmaraj,

Megha

2024

Preprint

View full text Add to dashboard Cite

Amla is a celebrated ethnobotanical fruit whose consumption is associated with several beneficial claims. Many studies have demonstrated Amla’s positive impact on molecular and systemic readouts in diseased conditions. Studies on Amla’s potential as a nutraceutical however are limited. To test if daily dietary supplementation with Amla improves select systemic readouts associated with wellbeing, and alleviate phenotypes associated with early life malnutrition, we deployed the fly animal model system. Benefits were compared between adult flies that were subject to larval starvation (ELS) and controls, and between genders. The most dramatic effect was observed in resistance to oxidative stress: prophylactic feeding of 1% Amla Juice (AJ) increased median survival by ∼75% (control) and 200% (ELS) in males, and ∼167% (control) and ∼150% (ELS) in females, respectively. Interestingly, survival also increased in both genders when AJ was fed only during stress or, before and during stress. For other assays, impacts were seen only in ELS flies: AJ feeding decreased lifespan in female ELS flies, increased egg numbers by ∼25% and improved survival uponP. entomophilainfection by ∼80%. Together, these suggest that prophylactic AJ dietary intake has selective biological effects and in the context of malnutrition, it can be explored further as a nutraceutical.Abstract Figure

show abstract

Exploration of metabolomics of Phyllanthus emblica: From ayurveda food to modern prospectives in quality control

Cited by 2 publications

References 80 publications

Chitosan in Oral Drug Delivery Formulations: A Review

Chitosan in Oral Drug Delivery Formulations: A Review

DietaryPhyllanthus emblica L.(Indian gooseberry, Amla) improves fecundity and resistance to oxidative stress in aDrosophila melanogastermodel of early-life malnutrition

Contact Info

Product

Resources

About