Exploration of Nicotine Metabolism in Paenarthrobacter nicotinovorans pAO1 by Microbial Proteomics

Mihășan, Marius; Babii, Cornelia; Aslebagh, Roshanak; Channaveerappa, Devika; Dupree, Emmalyn J.; Darie, Costel C.

doi:10.1007/978-3-030-15950-4_30

Cited by 2 publications

(2 citation statements)

References 87 publications

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“…By far, the most well-studied pathway is the one encoded by the pAO1 plasmid from P. nicotinovorans ATCC 49,919 [147]. Not only has the complete genome of the strain been sequenced [104], the NIC-induced proteome of the strain is also available [148][149][150]. On the pAO1 megaplasmid, the nic-genes cluster is flanked by integrases and consists of a 49 kb catabolic transposon [151] that was shown to spread the nic-genes from/to chromosomes and plasmids in soil bacteria [145].…”

Section: The Pyridine Pathway For Nicotine Degradationmentioning

confidence: 99%

Insights into Pharmacological Activities of Nicotine and 6-Hydroxy-L-nicotine, a Bacterial Nicotine Derivative: A Systematic Review

Boiangiu,

Brinza,

Honceriu

et al. 2023

Biomolecules

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The purported cognitive benefits associated with nicotine and its metabolites in the brain are a matter of debate. In this review, the impact of the pharmacologically active metabolite of a nicotine derivative produced by bacteria named 6-hydroxy-L-nicotine (6HLN) on memory, oxidative stress, and the activity of the cholinergic system in the brain was examined. A search in the PubMed, Science Direct, Web of Science, and Google Scholar databases, limiting entries to those published between 1992 and 2023, was conducted. The search focused specifically on articles about nicotine metabolites, memory, oxidative stress, and cholinergic system activity, as well as enzymes or pathways related to nicotine degradation in bacteria. The preliminary search resulted in 696 articles, and following the application of exclusion criteria, 212 articles were deemed eligible for inclusion. This review focuses on experimental studies supporting nicotine catabolism in bacteria, and the chemical and pharmacological activities of nicotine and its metabolite 6HLN.

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Section: The Pyridine Pathway For Nicotine Degradationmentioning

confidence: 99%

Insights into Pharmacological Activities of Nicotine and 6-Hydroxy-L-nicotine, a Bacterial Nicotine Derivative: A Systematic Review

Boiangiu,

Brinza,

Honceriu

et al. 2023

Biomolecules

View full text Add to dashboard Cite

show abstract

“…By far, the most well-studied pathway is the one encoded by the pAO1 plasmid from P. nicotinovorans ATCC 49919 [118] Not only that the complete genome of the strain was sequenced [80] but also the nicotine-induced proteome of the strain is available [119][120][121] On the pAO1 megaplasmid, the nic-genes cluster is flanked by integrases and consists of a 49 kb catabolic transposon [122] that was shown to be spreading the nic-genes from/to chromosomes and plasmids in soil bacteria [116] It has been suggested that this catabolic transposon has been transferred into pAO1 from the chromosome of a bacterium possibly related to Rhodococcus, Arthrobacter, or Penarthrobacter [116,117,123].…”

Section: The Pyridine Pathway For Nicotine Degradationmentioning

confidence: 99%

Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine

Boiangiu,

Brinza,

Honceriu

et al. 2023

Preprint

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The purported cognitive benefits associated with nicotine and its metabolites in the brain are a matter of debate. In this review, the impact of the pharmacologically active metabolite of a nicotine derivative produced by bacteria (6-hydroxy-L-nicotine) on memory, oxidative stress, and the activity of the cholinergic system in the brain was examined. A search in the PubMed, Science Direct, Web of Science, and Google Scholar databases, limiting entries to those no later than July 2023, was conducted. The search focused specifically on articles pertaining to nicotine metabolites, memory, oxidative stress, cholinergic system activity, as well as enzymes or pathways related to nicotine degradation in bacteria. The preliminary search resulted in 696 articles, and following the application of exclusion criteria, 185 articles were deemed eligible for inclusion. This review focuses on experimental studies supporting nicotine catabolism in bacteria, and the chemical and pharmacological activities of nicotine and its metabolite 6-hydroxy-L-nicotine.

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Exploration of Nicotine Metabolism in Paenarthrobacter nicotinovorans pAO1 by Microbial Proteomics

Cited by 2 publications

References 87 publications

Insights into Pharmacological Activities of Nicotine and 6-Hydroxy-L-nicotine, a Bacterial Nicotine Derivative: A Systematic Review

Insights into Pharmacological Activities of Nicotine and 6-Hydroxy-L-nicotine, a Bacterial Nicotine Derivative: A Systematic Review

Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine

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