Exploration of novel anti-angiogenic PEDF-derived peptides with improved activitives by inhibiting proliferation, suppressing migration, and inducing 67LR internalization

Shi, Wei; Li, Jiuhui; Zhou, Jiaqi; Li, Yuanyuan; Lin, Haiyan; Qian, Hai; Fan, Wen

doi:10.1016/j.bioorg.2021.105323

Cited by 4 publications

(1 citation statement)

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“…Furthermore, topical instillation of PEDF reduces retinal ganglion cell death, Müller cell activation, and vascular leakage in diabetic mice retinas [ 139 ]. Recently, PEDF-derived peptides with angiogenic inhibitory activities have been developed for the translation of the PEDF treatment into clinical practice [ 140 ].…”

Section: Therapeutic Options For Nvu Impairments In Diabetic Retinopathymentioning

confidence: 99%

Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy

Oshitari

2021

IJERPH

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Diabetic retinopathy has recently been defined as a highly specific neurovascular complication of diabetes. The chronic progression of the impairment of the interdependence of neurovascular units (NVUs) is associated with the pathogenesis of diabetic retinopathy. The NVUs consist of neurons, glial cells, and vascular cells, and the interdependent relationships between these cells are disturbed under diabetic conditions. Clinicians should understand and update the current knowledge of the neurovascular impairments in diabetic retinopathy. Above all, neuronal cell death is an irreversible change, and it is directly related to vision loss in patients with diabetic retinopathy. Thus, neuroprotective and vasoprotective therapies for diabetic retinopathy must be established. Understanding the physiological and pathological interdependence of the NVUs is helpful in establishing neuroprotective and vasoprotective therapies for diabetic retinopathy. This review focuses on the pathogenesis of the neurovascular impairments and introduces possible neurovascular protective therapies for diabetic retinopathy.

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Section: Therapeutic Options For Nvu Impairments In Diabetic Retinopathymentioning

confidence: 99%