Exploration of Preliminary Phytochemical Studies of Seed of &lt;I&gt;syzygium cumini&lt;/I&gt;

Murti, Krishna; Paliwal, Deepika; Madan, Shyna; Kundu, Rekha; Kaushik, M. P.

doi:10.3844/ajptsp.2012.12.14

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…The current results of S. cumini could be comparable to those of other phytochemical studies conducted in different countries related to its different parts (Murti et al, 2012;Kamal, 2014;Prabakaran & Shanmugavel 2017;Aziz & Banerjee, 2018).…”

Section: Qualitative Analysis Of Phytochemicalssupporting

confidence: 90%

Comparative Phyto and Physicochemical Parameters of the Therapeutic Plant Syzygium cumini (L.) Skeels in Jaffna District

Gowri Rajkumar,

Mihiri R. Jayasinghe,

Vinotha Sanmugarajah

2023

VJScience

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Syzygium cumini (L.) Skeels (Myrtaceae) is an evergreen tree, grown widely in Sri Lanka. It is regularly recognized as jambolan, black plum, and jamun. It is an extensively used therapeutic herbal in the treatment of innumerable illnesses, particularly in Diabetes mellitus in traditional medicine. The goal of the research was to compare the phytochemical and physicochemical properties between the different parts of jambolana tree which is naturally found in Sri Lanka. Proximate estimation of physicochemical properties of dried matured different parts as bark, leaves, fruits, and seeds of the Syzygium cumini havebeen done in the current study rendering to the standard protocols recommended by the World Health Organization (WHO) and Association of Analytical Chemist (AOAC). This study includes electrical conductivity value, moisture content, fat content, and different ash contents analysis. It was found that the leaves had the highest electrical conductivity (16.67±1.53) and the bark had the lowest electrical conductivity (2.44±0.03). The moisture content of the bark was lower (11.30±0.44) in comparison tothat of the seeds (16.34±0.43). Furthermore, the bark had the highest fat content (1.02±0.03) and acid insoluble ash (2.65±0.89), when compared to the seeds (0.65±0.01) and leaves (1.00±0.88) respectively. The seeds had the highest pH (5.39±0.08); total ash (2.18±0.06) and water-soluble ash (5.25±0.55), while the fruits had the highest sulphated ash (1.99±0.55). Qualitative inspection revealed that hot ethanolic seed extracts contained high levels of flavonoids, tannins, phenols, glycosides, alkaloids, terpenoids and quinones, in addition to other parts, which also had high levels of alkaloid content (81.06 mg/g). The current study will contribute useful data in the precise documentation and validation of various parts of S. cumini and may aid in removing contaminants in the preparation of nutraceuticals or medicine. Keywords: Medicinal Plant, Parts, Parameters, Physicochemical, Phytochemical, Syzygium cumini

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Section: Qualitative Analysis Of Phytochemicalssupporting

confidence: 90%

Comparative Phyto and Physicochemical Parameters of the Therapeutic Plant Syzygium cumini (L.) Skeels in Jaffna District

Gowri Rajkumar,

Mihiri R. Jayasinghe,

Vinotha Sanmugarajah

2023

VJScience

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WHO prescribed shelf life assessment of Syzygium cumini extract through chromatographic and biological activity analyses

Kaur

Bansal

2020

Journal of Ayurveda and Integrative Medicine

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Background Regulatory guidelines recommend shelf life of herbal products to be established through systematic stability studies. Objective The study was designed to establish shelf life of Syzygium cumini extract through accelerated and long-term stability testing as per WHO guidelines. Material and methods The extract was stored under accelerated (40°C/75 %RH) and long-term (25°C/60 %RH) stability conditions for 6 and 30 months, respectively. Samples were withdrawn at periodic intervals and analysed through two validated HPLC-UV methods (I and II) for fingerprint and quantitative analysis of markers. Antidiabetic activity of control and stability samples was evaluated by α-glucosidase inhibitory model. Results Method I generated a well resolved fingerprint of the control sample that was found to contain gallic acid (GA, 1.45 % w/w) and ellagic acid (EA, 3.97 % w/w). The content of GA did not change under both the stability conditions, but that of EA varied insignificantly (3.97–4.77 % w/w) under long-term conditions up to 24 months and subsequently decrease to 3.15 % w/w after 30 months. There was no visible change in LC-UV fingerprint of any stability sample with respect to control. α-Glucosidase inhibitory activity of all stability samples also remained unaltered as compared to control sample (IC 50 1.48 mg/mL). GA and EA did not elicit any activity at the concentrations present in the extract. Conclusion Phytochemical composition and antidiabetic efficacy of S. cumini extract remain unchanged during its storage under both accelerated and long-term stability conditions, which suggest its shelf life to be 30 months. Also, GA and EA are not appropriate anti-diabetic markers.

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Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini

Kaur

Singla

Saini

et al. 2017

JPTRM

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An isocratic HPLC method was developed for standardization of five commercially available products containing S. cumini seeds (DIABECON, MADHULENE, HYPONIDD, D-FIT and DIABEGON)using methylxanthoxylin (MXX)as marker. The method was validated in accordance with ICH Q2(R1) guidelines. The chromatographic separation of MXX was achieved on a C18 column by mobile phase composed of methanol and water (60:40%v/v) at a flow rate 0.5 mL/min. The eluent was detected at 280 nm. The method was linear over concentration of 1-200 μg/mL with correlation coefficient of 0.9999. The LOD and LOQ were 0.175 and 0.530 µg/mL, respectively. The method was precise (%RSD <0.31), accurate and robust for determination of MXX in herbal extracts. The content of MXX in the seed extract was found to be 0.0433%w/w while it was ranging from 0.026- 0.041%w/w in the products. The content of MXX was found to be equivalent to the pure seed extract only in DIABECON tablets and D-FIT soft gelatine capsules while it was found to be significantly less in the other formulations.

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Exploration of Preliminary Phytochemical Studies of Seed of <I>syzygium cumini</I>

Cited by 5 publications

References 5 publications

Comparative Phyto and Physicochemical Parameters of the Therapeutic Plant Syzygium cumini (L.) Skeels in Jaffna District

Comparative Phyto and Physicochemical Parameters of the Therapeutic Plant Syzygium cumini (L.) Skeels in Jaffna District

WHO prescribed shelf life assessment of Syzygium cumini extract through chromatographic and biological activity analyses

Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini

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