Exploration of selected monoterpenes as potential TRPC channel family modulator in lung cancer, an
            <i>in-silico</i>
            upshot

Singh, Akanksha; Mishra, Anamika; Meena, Abha; Mishra, Nidhi; Luqman, Suaib

doi:10.1080/07391102.2023.2241900

Cited by 2 publications

(1 citation statement)

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“…An in silico study revealed that TRPC ion channels regulate invasion, migration, and abnormal proliferation. Apart from that, TQ exhibited the highest binding interaction with the TRPC 4 channel (Singh et al, 2023).…”

Section: Thymoquinonementioning

confidence: 96%

Monoterpenoids: An upcoming class of therapeutic agents for modulating cancer metastasis

Mathur,

Meena,

Luqman

2023

Phytotherapy Research

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Monoterpenoids, a sub‐class of terpenoids, are secondary metabolites frequently extracted from the essential oils of aromatic plants. Their antitumor properties including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects along with other biological activities have been the subject of extensive study due to their diverse characteristics. In recent years, numerous investigations have been conducted to understand its potential anticancer impacts, specifically focusing on antiproliferative and apoptotic mechanisms. Metastasis, a malignancy hallmark, can exert either protective or destructive influences on tumor cells. Despite this, the potential antimetastatic and antiangiogenic attributes of monoterpenoids need further exploration. This review focuses on specific monoterpenoids, examining their effects on metastasis and relevant signaling pathways. The monoterpenoids exhibit a high level of complexity as natural products that regulate metastatic proteins through various signaling pathways, including phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin, mitogen‐activated protein kinase/extracellular signal‐regulated kinase/jun N‐terminal kinase, nuclear factor kappa B, vascular endothelial growth factor, and epithelial mesenchymal transition process. Additionally, this review delves into the biosynthesis and classification of monoterpenoids, their potential antitumor impacts on cell lines, the plant sources of monoterpenoids, and the current status of limited clinical trials investigating their efficacy against cancer. Moreover, monoterpenoids depict promising potential in preventing cancer metastasis, however, inadequate clinical trials limit their drug usage. State‐of‐the‐art techniques and technologies are being employed to overcome the challenges of utilizing monoterpenoids as an anticancer agent.

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Section: Thymoquinonementioning

confidence: 96%