Background There is growing interest in examining the factors affecting the reporting of errors by nurses. However, little research has been conducted into the effects of perceived patient safety culture and leader coaching behavior of nurses on the intention to report errors.Methods This cross-sectional study was conducted amongst 256 nurses in the emergency departments of 18 public and private hospitals in Tabriz, northwest Iran. Participants completed the self- administered questionnaires and the data was analyzed using linear regression analysis.Results Overall, 43% of nurses had an intention to report errors; 50% of respondents reported that their nursing managers demonstrated high levels of coaching. With regard to patient safety culture, areas of strength and weakness were “Teamwork within Units” (PRR = 66.80%) and “Non-punitive response errors” (PRR = 19.66%). Regression findings highlighted a significant association between an intention to report errors and patient safety culture (B=0.123, CI 95%: 0.005 to 0.328, P = 0.026), leader coaching behavior (B=0.172, CI 95%: 0.066 to 0.347, P = 0.004) and nurses’ educational status (B=0. 787, 95% CI: -.064 to 1.638, P = 0.048). Conclusions Further research is needed to assess how interventions addressing patient safety culture and leader coaching behaviors might increase the intention to report errors.