Exploration of the heat generation within the intensified vibratory mill

Cleyn, Elene De; Holm, René; Mooter, Guy Van den

doi:10.1016/j.ijpharm.2020.119644

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Nonetheless, the PSDs evolved differently during storage where sample 3 remained stable throughout the whole study whereas an indispersible cake materialised in sample 6. The temperature after production, retrieved as explained in prior work (De Cleyn et al, 2020) was distinct with a value of 40.1°C and 66.2°C for sample 3 and 6, respectively. As an increased temperature might lead to the (partial) desolvation of the hydrophilic part of the applied surfactant, it might have rendered its stabilisation efficacy.…”

Section: Resultsmentioning

confidence: 82%

Shedding a light on the physical stability of suspensions micronised with intensified vibratory milling; A trend observed with decreasing particle size as a function of time

Cleyn

Holm

Mooter

2021

International Journal of Pharmaceutics

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Section: Resultsmentioning

confidence: 82%

Shedding a light on the physical stability of suspensions micronised with intensified vibratory milling; A trend observed with decreasing particle size as a function of time

Cleyn

Holm

Mooter

2021

International Journal of Pharmaceutics

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A Systematic Investigation of Process Parameters for Small-Volume Aqueous Suspension Production by the Use of Focused Ultrasonication

Zulbeari,

Holm

2024

AAPS PharmSciTech

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Aqueous suspensions containing crystalline drug in the sub-micron range is a favorable platform for long-acting injectables where particle size can be used to obtain a desired plasma-concentration profile. Stabilizers are added to the suspensions and screened extensively to define the optimal formulation composition. In the initial formulation screening the amount of drug compound can be limited, necessitating milling methods for small-volume screening predictable for scale-up. Hence, adaptive focused ultrasound was investigated as a potential milling method for rapid small-volume suspensions by identifying the critical process parameters during preparation. Suspensions containing drug compounds with different mechanical properties and thereby grindability, i.e., cinnarizine, haloperidol, and indomethacin with brittle, elastic, and plastic properties, respectively, were investigated to gain an understanding of the manufacturing with adaptive focused acoustics as well as comparison to already established milling techniques. Using a DoE-design, peak incident power was identified as the most crucial process parameter impacting the milling process for all three compounds. It was possible to decrease the sizes of drug particles to micron range after one minute of focused ultrasound exposure which was superior compared to other milling techniques (e.g., non-focused ultrasound exposure). The addition of milling beads decreased the drug particle sizes even further, thus to a lower degree than other already established milling techniques such as milling by dual centrifugation. This study thereby demonstrated that adaptive focused ultrasonication was a promising method for rapid homogenization and particle size reduction to micron range for different compounds varying in grindability without altering the crystalline structure. Graphical Abstract

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Exploration of the heat generation within the intensified vibratory mill

Cited by 2 publications

References 23 publications

Shedding a light on the physical stability of suspensions micronised with intensified vibratory milling; A trend observed with decreasing particle size as a function of time

Shedding a light on the physical stability of suspensions micronised with intensified vibratory milling; A trend observed with decreasing particle size as a function of time

A Systematic Investigation of Process Parameters for Small-Volume Aqueous Suspension Production by the Use of Focused Ultrasonication

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