Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?

Abstract

Oral or gastrointestinal mucositis is a frequent phenomenon in cancer patients receiving chemotherapy or radiotherapy. In addition, several clinical investigations have demonstrated in recent years that riboflavin laurate has the potential to protect the patients from the disease induced by chemotherapy or radiotherapy. In our studies, it is observed that riboflavin laurate can ameliorate either chemotherapy- or radiotherapy-induced toxicities on Helf cells, and the effect is greater than that of riboflavin. In addition, riboflavin laurate is able to transport through the Caco-2 cell monolayer as the prototype, indicating the protective effects may be produced by the prototype of riboflavin laurate, rather than simply by the released riboflavin.

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy

“…It is interesting to note that these lifespan and locomotor defects are rescued by ingestion of an esterified derivative of riboflavin, since this provides further evidence that the phenotypic signatures of drift knockdown flies are linked to riboflavin deficiency and consequent downstream metabolic defects. RLAM fulfils the criteria for being a treatment targeting energy metabolism, a fundamental mitochondrial process, in addition to circumventing the disease-related protein, features generally believed to be of great promise ( Lin and Beal, 2006 ; Xuan et al , 2013 ; Foley et al , 2014 ).…”

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

“…In addition, RF laurate has protective and therapeutic properties against radiotherapy-induced toxicity on human embryonic lung fibroblasts (Helf cells) [73].…”

Prophylactic Treatment with Vitamins C and B2 for Methotrexate-Induced Gastrointestinal Mucositis

“…In a study performed by Xuan et al, 2013 human embryonic lung fibroblasts (Helf cells) were irradiated and then incubated with different concentrations of riboflavin laureate and their proliferative properties were investigated. Results show that when higher concentrations of this compound are added to the cultures, proliferation rates increase significantly suggesting that on a cellular level, riboflavin laureate can enhance cell proliferation in both oral and gastrointestinal mucositis [ 37 ]. In a prospective clinical study by von Martels et al, 2019 vitamin B2 supplementation in Crohn’s disease patients resulted in reduced systemic oxidative stress and clinical symptoms, suggesting that this vitamin has the capability to improve inflammatory conditions.…”