Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling

Tinette, Sylvette; Zhang, Lixing; Garnier, Amélie; Engler, Gilbert; Tarès, Sophie; Robichon, Alain

doi:10.1186/1471-2202-8-65

Cited by 10 publications

(9 citation statements)

References 39 publications

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“…1a). We tested the effect of water (used as a “empty control” substance), plain laboratory food, grape juice and acetic acid (two potentially attractive substances3334) and yeast (an active component of plain food). We also measured the effect of acetoin, a volatile molecule—alone or mixed at two concentrations with plain food—produced both by fermenting fruits and by Drosophila larvae3536.…”

Section: Resultsmentioning

confidence: 99%

Free flight odor tracking in Drosophila: Effect of wing chemosensors, sex and pheromonal gene regulation

Houot

Gigot

Robichon

et al. 2017

Sci Rep

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The evolution of powered flight in insects had major consequences for global biodiversity and involved the acquisition of adaptive processes allowing individuals to disperse to new ecological niches. Flies use both vision and olfactory input from their antennae to guide their flight; chemosensors on fly wings have been described, but their function remains mysterious. We studied Drosophila flight in a wind tunnel. By genetically manipulating wing chemosensors, we show that these structures play an essential role in flight performance with a sex-specific effect. Pheromonal systems are also involved in Drosophila flight guidance: transgenic expression of the pheromone production and detection gene, desat1, produced low, rapid flight that was absent in control flies. Our study suggests that the sex-specific modulation of free-flight odor tracking depends on gene expression in various fly tissues including wings and pheromonal-related tissues.

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Section: Resultsmentioning

confidence: 99%

Free flight odor tracking in Drosophila: Effect of wing chemosensors, sex and pheromonal gene regulation

Houot

Gigot

Robichon

et al. 2017

Sci Rep

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“…Previous research on flies suggests that the complexity of food search behaviour is not an individual process but requires social interactions between individuals [46], [47]. For example, social interactions between flies impacts what specific food patches are chosen [46].…”

Section: Discussionmentioning

confidence: 99%

Social Environment Influences Performance in a Cognitive Task in Natural Variants of the Foraging Gene

et al. 2013

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In Drosophila melanogaster, natural genetic variation in the foraging gene affects the foraging behaviour of larval and adult flies, larval reward learning, adult visual learning, and adult aversive training tasks. Sitters (for s) are more sedentary and aggregate within food patches whereas rovers (forR) have greater movement within and between food patches, suggesting that these natural variants are likely to experience different social environments. We hypothesized that social context would differentially influence rover and sitter behaviour in a cognitive task. We measured adult rover and sitter performance in a classical olfactory training test in groups and alone. All flies were reared in groups, but fly training and testing were done alone and in groups. Sitters trained and tested in a group had significantly higher learning performances compared to sitters trained and tested alone. Rovers performed similarly when trained and tested alone and in a group. In other words, rovers learning ability is independent of group training and testing. This suggests that sitters may be more sensitive to the social context than rovers. These differences in learning performance can be altered by pharmacological manipulations of PKG activity levels, the foraging (for) gene's gene product. Learning and memory is also affected by the type of social interaction (being in a group of the same strain or in a group of a different strain) in rovers, but not in sitters. These results suggest that for mediates social learning and memory in D. melanogaster.

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“…In D. melanogaster, Gycα-99B and Gycβ-100B are orthologs of the α1 and β1 subunits, respectively. Drosophila mutants deficient in the production of these proteins suggest that the NO/cGMP pathway mediates a behavioral phenotype (52) and development of the visual system (53), and this pathway is important for larval foraging locomotion (54). In other organisms, several biochemical studies have been aimed at elucidating the significance of the NO/cGMP-signaling pathway.…”

Section: Soluble Guanylate Cyclase Isoformsmentioning

confidence: 99%

Structure and Regulation of Soluble Guanylate Cyclase

Derbyshire

Marletta

2012

Annu. Rev. Biochem.

398

329

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Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it functions as the primary activator of soluble guanylate cyclase (sGC). NO is synthesized from l-arginine and oxygen (O(2)) by the enzyme nitric oxide synthase (NOS). Once produced, NO rapidly diffuses across cell membranes and binds to the heme cofactor of sGC. sGC forms a stable complex with NO and carbon monoxide (CO), but not with O(2). The binding of NO to sGC leads to significant increases in cGMP levels. The second messenger then directly modulates phosphodiesterases (PDEs), ion-gated channels, or cGMP-dependent protein kinases to regulate physiological functions, including vasodilation, platelet aggregation, and neurotransmission. Many studies are focused on elucidating the molecular mechanism of sGC activation and deactivation with a goal of therapeutic intervention in diseases involving the NO/cGMP-signaling pathway. This review summarizes the current understanding of sGC structure and regulation as well as recent developments in NO signaling.

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Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling

Cited by 10 publications

References 39 publications

Free flight odor tracking in Drosophila: Effect of wing chemosensors, sex and pheromonal gene regulation

Free flight odor tracking in Drosophila: Effect of wing chemosensors, sex and pheromonal gene regulation

Social Environment Influences Performance in a Cognitive Task in Natural Variants of the Foraging Gene

Structure and Regulation of Soluble Guanylate Cyclase

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