Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP)

Kłodzińska, Aleksandra; Jaros, T.; Chojnacka-Wójcik, E; J, Maj

doi:10.1007/bf02248670

Cited by 29 publications

(21 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The animals were then placed into 30 ϫ 30 cm 2 Plexiglas chambers for 15 min and changes in the animals' behavior were monitored to allow for observation of any changes in behavior produced by the pretreatment compound alone. Previous studies have shown that 15 min was sufficient to allow for maximum behavioral and/or biochemical effects of the compounds tested (3,9,10). In addition, our behavioral observations indicated that 15 min was sufficient time to observe behavioral effects of these compounds.…”

Section: Behavioral Observationssupporting

confidence: 65%

The Role of Serotonin2 Receptors in Mediating Cocaine-Induced Convulsions

O’Dell

Kreifeldt

George

et al. 2000

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Previous research in our laboratory suggests that serotonin (5-HT) neurotransmission mediates the expression of cocaine-induced convulsions. The role of 5-HT in mediating this toxic effect of cocaine appears to be due to activation of 5-HT(2) receptors, because cocaine-induced convulsions are blocked by the 5-HT(2) antagonists cinanserin, ketanserin, and pirenperone. The present study utilized a number of compounds that display a high affinity for 5-HT(2) receptors to further examine the role of these sites in mediating this toxic effect of cocaine. Cocaine-induced convulsions were observed following pretreatment with various doses of the following 5-HT(2) antagonists: mianserin, metergoline, MDL 11939, and methiothepin. In addition, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (NAN 190) was tested to examine the influence of 5-HT(1) sites and the agonist compound 1-(3-triflurormethylphenyl)piperazine (TFMPP) was examined to further explore the role of 5-HT(1) and 5-HT(2) sites. Each 5-HT(2) antagonist attenuated cocaine-induced convulsions. Conversely, NAN 190 did not alter this toxic effect of cocaine. In addition, TFMPP significantly potentiated cocaine-induced convulsions. The results from this study support the hypothesis that 5-HT neurotransmission, acting primarily at 5-HT(2) receptors, plays an important role in mediating cocaine-induced convulsions.

show abstract

Section: Behavioral Observationssupporting

confidence: 65%

The Role of Serotonin2 Receptors in Mediating Cocaine-Induced Convulsions

O’Dell

Kreifeldt

George

et al. 2000

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…The exploratory hypoactivity induced by m-CPP is considered to be mediated by 5-HTlc receptors (Kennett and Curzon, 1988;Ktodzifiska et al, 1989). Both sertraline and citalopram given repeatedly inhibited that effect, which may indicate that the sensitivity of 5-HTlc receptors decreases.…”

Section: Discussionmentioning

confidence: 95%

Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations

Moryl

1992

J. Neural Transmission

Self Cite

View full text Add to dashboard Cite

The effect of repeated treatment (5 and 10 mg/kg, po, twice daily, 14 days) with sertraline and citalopram (antidepressants which selectively inhibit the reuptake of 5-hydroxytryptamine (5-HT)) on the responsiveness of different 5-HT receptors to their agonists, was examined in rats and mice. Sertraline and citalopram (both at a dose 5 and 10 mg/kg) antagonized (the first one more potently) the hypothermia induced in mice by 8-OH-DPAT (a 5-HT1A agonist), but not the behavioural syndrome induced in rats by this substance. The m-chlorophenylpiperazine-induced hypothermia in mice (a 5-HT1B effect) was increased by sertraline and citalopram (only in a dose of 10 mg/kg). Both antidepressants, given repeatedly (as well acutely) attenuated exploratory hypoactivity induced in rats by m-chlorophenylpiperazine (a 5-HT1C effect). L-5-HTP-induced head twitches in mice (5-HT2 effect) were antagonized dose-dependently by both repeated sertraline and citalopram. Both antidepressants (citalopram only in higher dose) reduced the fenfluramine-induced hyperthermia in rats (5-HT2 effect). The results indicate that sertraline and citalopram given repeatedly decrease the responsiveness of 5-HT1A (presynaptic) and 5-HT2 receptors but increase the responsiveness of 5-HT1B receptors to respective agonists.

show abstract

“…Mesulergine, ritanserin, and ketanserin, in a range of doses similar to those used in our experiments, attenuated or even completely blocked the anorexia induced by TFMPP in freely feeding rats, an effect in which 5-HT1, andfor 5-HT2 receptors are involved (Klodzinska and Chojnacka-Wojcik, 1990). Moreover, mesulergine, but not ritanserin, administered at the same doses used in this study, antagonized TFMPP-induced hypoactivity in rats, an effect mediated by 5-HT1, receptors (Klodzinska et al, 1989). On the other hand, only high doses of spiperone, such as those necessary to block the anticonvulsant effect of TFMPP, were reported to antagonize TFMPP-induced hyperthermia in heatadapted rats, a response mediated mainly by 5-HT2 receptors (Klodzinska and Chojnacka-Wojcik, 1992).…”

Section: Discussionmentioning

confidence: 48%

Role of 5‐Hydroxytryptamine Receptor Subtypes in the 1‐[3‐(Trifluoromethyl)Phenyl] Piperazine‐Induced Increase in Threshold for Maximal Electroconvulsions in Mice

1994

View full text Add to dashboard Cite

The effect of 1-[3-(trifluoromethyl)phenyl] piperazine (TFMPP), a 5-hydroxytryptamine (5-HT) receptor agonist, on the threshold for maximal electroconvulsions was studied in mice. TFMPP in intraperitoneal (i.p.) doses of 10, 20 and 40 mg/kg increased the convulsive threshold (the amperage necessary to produce the hindleg tonic extensor component of seizures in 50% of animals) by 28, 60, and 85%, respectively. The effect of TFMPP (20 mg/kg) was dose-dependently blocked by 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine (NAN-190), prazosin, spiperone, mesulergine, ketanserin, and ritanserin. On the other hand, pindolol and cyanopindolol had no effect on the convulsive threshold increased by TFMPP. The results indicate that the TFMPP-induced decrease in the susceptibility to seizures is connected to stimulation of 5-HT2 or of both 5-HT1C and 5-HT2 receptors. Moreover, alpha 1-adrenoceptors also appear to be engaged in this effect.

show abstract

Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP)

Cited by 29 publications

References 14 publications

The Role of Serotonin2 Receptors in Mediating Cocaine-Induced Convulsions

The Role of Serotonin2 Receptors in Mediating Cocaine-Induced Convulsions

Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations

Role of 5‐Hydroxytryptamine Receptor Subtypes in the 1‐[3‐(Trifluoromethyl)Phenyl] Piperazine‐Induced Increase in Threshold for Maximal Electroconvulsions in Mice

Contact Info

Product

Resources

About