Exploratory study of long‐term health‐related quality of life in patients with surgically treated primary parotid gland cancer

Stenner, Markus; Beenen, Franziska; Hahn, Moritz; Koopmann, Matthias; Weiß, Daniel; Hüttenbrink, Karl-Bernd

doi:10.1002/hed.23858

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…Patients already with a preoperative PFP had a statistically and clinically worse QoL in the scales of global health status (no PFP: 67.5, PFP: 52.6; P = .032), swallowing (6.6 vs. 20.1; P = .012), social eating (10.6 vs. 26.9; P = .009), social contact (13.2 vs. 27.3; P = .032), and dry mouth (31.2 vs. 64.1; P = .009). Postoperative PFP was associated with a reduced QoL on the social contact domain (respectively, 20.2 vs. 8.5; P = .017) …”

Section: Resultsmentioning

confidence: 99%

“…The study by Ryzenman et al did not include any treatment for patients with a PFP, and the study of Leong and Lesser was a survey among PFP patients. In total, 12 studies were included in this systematic review . Due to heterogeneity of patient populations, we performed a meta‐analysis of the surgical studies using the FaCE scale as a QoL measurement.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 12 included studies, nine had a prospective study design, and three had a retrospective study design . In total, one study reported the effect of mime therapy (form of physical therapy) on QoL, one study reported the effect of corticosteroids, two studies reported the effect of treatment with botulinum toxin injections, and eight studies reported the effect of surgical procedures …”

Section: Resultsmentioning

confidence: 99%

“…In total, 12 studies were included in this systematic review. [15][16][17][18][19][20][21][22][23][24][25][26] Due to heterogeneity of patient populations, we performed a meta-analysis of the surgical studies using the FaCE scale as a QoL measurement. Figure 1 summarizes the search results.…”

Section: Resultsmentioning

confidence: 99%

“…[23][24][25] In total, one study reported the effect of mime therapy (form of physical therapy) on QoL, 23 one study reported the effect of corticosteroids, 21 two studies reported the effect of treatment with botulinum toxin injections, 20,22 and eight studies reported the effect of surgical procedures. [15][16][17][18][19][20][21][22][23][24][25][26]…”

Section: Study Design and Treatment Modalitiesmentioning

confidence: 99%

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Quality of life before and after different treatment modalities in peripheral facial palsy: A systematic review

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Design and Treatment Modalitiesmentioning

confidence: 99%

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Quality of life before and after different treatment modalities in peripheral facial palsy: A systematic review

et al. 2016

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Risk factors associated with patient‐reported fatigue among long‐term oropharyngeal carcinoma survivors

et al. 2022

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Background The study objective is to identify risk factors associated with fatigue among long‐term OPC survivors. Methods This cross‐sectional study included disease‐free OPC survivors treated curatively between 2000 and 2013 who were surveyed from September 2015 to July 2016. The outcome variable was patient‐reported fatigue. Multivariable logistic regression was used to identify factors associated with moderate to severe fatigue. Results Among 863 OPC survivors, 17.4% reported moderate to severe fatigue. Self‐reported thyroid problems (OR: 2.01; p = 0.003), current cigarette smoking at time of survey (OR: 3.85; p = 0.001), late lower cranial neuropathy (OR: 3.44; p = 0.002), and female sex (OR: 1.91; p = 0.010) were concurrent risk factors of reporting moderate to severe fatigue. Ipsilateral intensity‐modulated radiotherapy (OR: 0.18; p = 0.014) was associated with lower risk of reporting moderate to severe fatigue. Conclusions Our study identified thyroid problems, smoking, and late lower cranial neuropathy as associated with moderate to severe fatigue. These findings should be further validated in prospective studies to address fatigue among OPC survivors.

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Quality of Life Outcomes for Parotid Malignancies

Tang,

Li,

Scheff

et al. 2024

The Laryngoscope

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BackgroundThis study describes patient‐reported outcome measures (PROMs) and associated factors in patients who underwent surgery for malignant parotid tumors (MPT).MethodsThis is a retrospective study of all surgically treated MPT patients in a multidisciplinary head and neck cancer (HNC) survivorship clinic (2017–2023). PROMs included University of Washington Quality of Life Questionnaire (UW‐QOL), Eating Assessment Tool (EAT‐10), Patient Health Questionnaire (PHQ‐8), Generalized Anxiety Disorder (GAD‐7), Neck Disability Index (NDI), and Insomnia Severity Index. Multivariable regression analysis was used to investigate clinical predictors associated with PROMs.ResultsIn 62 MPT patients, the prevalence of clinically relevant dysphagia symptoms (EAT‐10), elevated symptoms of depression (PHQ‐8), moderate/severe symptoms of anxiety (GAD‐7), moderate/severe neck pain with activities of daily living (NDI), and moderate/severe symptoms of insomnia at last follow‐up was 32.3%, 15.5%, 7.1%, 17.7%, and 7.2%, respectively. Nonparametric one‐sided test revealed that patients treated with adjuvant CRT had significantly worse physical QOL, social‐emotional QOL, and swallowing scores than patients treated with surgery alone (p = 0.01, p = 0.02, p = 0.03, respectively); that patients treated with surgery and adjuvant RT had significantly worse physical QOL and social‐emotional QOL than patients treated with surgery alone (p < 0.01, p = 0.01, respectively) and that patients treated with surgery and adjuvant CRT had significantly worse swallowing and neck pain than patients treated with surgery and adjuvant RT (p = 0.03, p = 0.05, respectively).ConclusionsIn patients with surgically treated MPT, adjuvant CRT and RT were associated with worse PROMs.Level of Evidence4 Laryngoscope, 2024

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Exploratory study of long‐term health‐related quality of life in patients with surgically treated primary parotid gland cancer

Abstract: In parotid gland cancer surgery, factors, such as sex, age, type of surgery, facial nerve palsy, and radiation therapy, seem to be associated with clinically meaningful differences in long-term HRQOL scores.

Cited by 12 publications

References 28 publications

Quality of life before and after different treatment modalities in peripheral facial palsy: A systematic review

Quality of life before and after different treatment modalities in peripheral facial palsy: A systematic review

Risk factors associated with patient‐reported fatigue among long‐term oropharyngeal carcinoma survivors

Quality of Life Outcomes for Parotid Malignancies

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