The evolution of corporate practices has made it more challenging for modern workers to remain in their respective roles for long periods, leading to high turnover. Accordingly, the employee turnover problem can be investigated by assessing the factors that encourage employees to shift from the safe and calm state to the fight or flight state. The Polyvagal Theory (PVT) is an innovative framework for understanding the relationship between the autonomic nervous system, emotional regulation, and social engagement. This study’s primary objective is to investigate the emerging trends in modern human resource management practices that encourage workers to resign prematurely. The findings divulge that the PVT can allow organizations to improve employee retention by implementing strategies that appeal to the workers’ psychological and emotional wellbeing.