Explore the Relationship Between Short-Term Ambient Air Pollution Exposure and Daily Outpatient Visits for Metabolic Related Fatty Liver

Wang, Ming Wei; Sun, Liang; Wen, Wen; Wang, Jie; Wang, Chunyi; Ni, Jie; Jiang, Jingjie; Feng, Zhanhui; Cheng, Yongran

doi:10.2147/rmhp.s364270

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…4 Another recent study suggested gender-specific effects of short-term environmental PM2.5 exposure on outpatient visits for metabolic-related fatty liver disease. 5 These results implicate that the effect of PM2.5 exposure on the risk of NAFLD may be sex specific. However, Li et al have not addressed the effect of gender on the association between ambient air pollutant exposure and the risk of NAFLD in this study.…”

Section: E T T E R T O T H E E D I T O R Air Pollutant Exposure and N...mentioning

confidence: 89%

Air pollutant exposure and non‐alcoholic fatty liver disease: Sex considerations

Liu

Chen

2023

Liver International

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Section: E T T E R T O T H E E D I T O R Air Pollutant Exposure and N...mentioning

confidence: 89%

Air pollutant exposure and non‐alcoholic fatty liver disease: Sex considerations

Liu

Chen

2023

Liver International

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“… 41 , 42 Further, other epidemiological studies also described the relationship between AP exposure and NAFLD. One study from Wang et al 20 examined the association between short-term exposure to different air pollutants and the number of outpatient visits for MASLD, and found that an increase in short-term AP exposure was related to outpatients visit for MASLD. 20 Similar to our study, another epidemiological study with 90,086 participants looked with a cross-sectional design at long-term exposure to AP and MASLD and found that long-term exposure to ambient PM (PM 10 , PM 2.5 , and PM 1 ) and NO 2 was positively associated with an increased risk of MASLD and is therefore in line with our findings, even though HS was diagnosed via abdominal ultrasound and not with FLI.…”

Section: Discussionmentioning

confidence: 99%

“…9,[11][12][13] Moreover, some epidemiological studies showed an association between long-term AP and metabolic syndrome, but to our knowledge, few epidemiological studies looked at an association between AP and NAFLD. 8,[14][15][16][17][18][19][20][21][22] The aim of this study was to investigate whether long-term exposure to AP is associated with NAFLD prevalence in the general adult population, using data from the population-based prospective Heinz-Nixdorf-Recall (HNR) cohort study in Germany, an ongoing prospective population-based cohort study.…”

Section: Introductionmentioning

confidence: 99%

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Long-term exposure to air pollution and prevalent nonalcoholic fatty liver disease

Matthiessen,

Glaubitz,

Lucht

et al. 2023

Environmental Epidemiology

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Background: Nonalcoholic fatty liver disease (NAFLD) is a disease characterized by lipid accumulation within hepatocytes, ranging from simple steatosis to steatohepatitis, in the absence of secondary causes of hepatic fat accumulation. Although air pollution (AP) has been associated with several conditions related to NAFLD (e.g., metabolic syndrome, type 2 diabetes mellitus), few studies have explored an association between AP and NAFLD. The aim of the study was to investigate whether exposure to AP is associated with NAFLD prevalence. Methods: We used baseline cross-sectional data (2000–2003) of the Heinz–Nixdorf–Recall cohort study in Germany (baseline n = 4,814), a prospective population-based cohort study in the urbanized Ruhr Area. Mean annual exposure to size-fractioned particulate matter (PM10, PM2.5, PMcoarse, and PM2.5abs), nitrogen dioxide, and particle number was assessed using two different exposure models: a chemistry transport dispersion model, which captures urban background AP exposure on a 1 km2 grid at participant’s residential addresses, and a land use regression model, which captures point-specific AP exposure at participant’s residential addresses. NAFLD was assessed with the fatty liver index (n = 4,065), with NAFLD defined as fatty liver index ≥60. We estimated ORs of NAFLD per interquartile range of exposure using logistic regression, adjusted for socio-demographic and lifestyle variables. Results: We observed a NAFLD prevalence of 31.7% (n = 1,288). All air pollutants were positively associated with NAFLD prevalence, with an OR per interquartile range for PM2.5 of 1.11 (95% confidence interval [CI] = 1.00, 1.24) using chemistry transport model, and 1.06 (95% CI = 0.94, 1.19) using the land use regression model, respectively. Conclusion: There was a positive association between long-term AP exposure and NAFLD.

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“…Although gender has been demonstrated to be linked to fatty liver, the evidence for PM 2.5 on the risk of MAFLD incidence in the female population remains unclear, and studies in this regard are somewhat inconsistent(B. Guo et al, 2022;Tong, Li, & Zhou, 2015;Wang et al, 2022). A study showed that the levels of genes expression differ between males and females exposed to AP (Vrijens et al, 2017), and females are more sensitive to liver disease (Tong et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Exposure to PM 2.5 and its constituents is associated with metabolic dysfunction-associated fatty liver disease: A cohort study in Northwest of China

Zhao

Peng

Wang

et al. 2023

Preprint

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Background Accumulating animal studies have demonstrated associations between ambient air pollution (AP) and metabolic dysfunction-associated fatty liver disease (MAFLD), but relevant epidemiological evidence is limited. We evaluated the association of long-term exposure to AP with the risk of incident MAFLD in Northwest China. Methods The average AP concentration between baseline and follow-up was used to assess individual exposure levels. Cox proportional hazard models and restricted cubic spline functions (RCS) were used to estimate the association of PM2.5 and its constituents with the risk of MAFLD and the dose-response relationship. Quantile g-computation was used to assess the joint effects of mixed exposure to air pollutants on MAFLD and the weights of the various pollutants. Results We observed 1516 cases of new-onset MAFLD, with an incidence of 10.89%. Increased exposure to pollutants was significantly associated with increased odds of MAFLD, with hazard ratios (HRs) of 2.93 (95% CI: 1.22, 7.00), 2.86 (1.44, 5.66), 7.55 (3.39, 16.84), 4.83 (1.89, 12.38), 3.35 (1.35, 8.34), 1.89 (1.02, 1.62) for each interquartile range increase in PM2.5, SO42−, NO3−, NH4+, OM, and BC, respectively. Stratified analyses suggested that females, frequent exercisers and never-drinkers were more susceptible to MAFLD associated with ambient PM2.5 and its constituents. Mixed exposure to SO42−, NO3−, NH4+, OM and BC was associated with an increased risk of MAFLD, and the weight of BC had the strongest effect on MAFLD. Conclusions Exposure to ambient PM2.5 and its constituents increased the risk of MAFLD.

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Explore the Relationship Between Short-Term Ambient Air Pollution Exposure and Daily Outpatient Visits for Metabolic Related Fatty Liver

Cited by 9 publications

References 36 publications

Air pollutant exposure and non‐alcoholic fatty liver disease: Sex considerations

Air pollutant exposure and non‐alcoholic fatty liver disease: Sex considerations

Long-term exposure to air pollution and prevalent nonalcoholic fatty liver disease

Exposure to PM 2.5 and its constituents is associated with metabolic dysfunction-associated fatty liver disease: A cohort study in Northwest of China

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