Exploring 5-nitrofuran derivatives against nosocomial pathogens: Synthesis, antimicrobial activity and chemometric analysis

Antimicrobial and antiprotozoal activity of 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines: a review

“…Four among five derivatives tested showed two times higher activity (MIC = 4.0-8.0 µM) than nifuroxazide (MIC = 8.0-16.0 µM), but lower than vancomycin used as reference compound (MIC = 2.0 µM) (Fig. 16,Table 4) (Zorzi et al 2014).…”

“…Due to this the most important thing is to discover new molecules with activity against resistant bacterial strains, which are responsible for high morbidity and mortality (Velázquez-Meza 2005). Zorzi et al (2014) synthesized two series of 5-nitrofuran derivatives with 3-acetyl-1,3,4-oxadiazole moiety. Their antibacterial activity was established on the basis of MIC values against following bacterial strains: K. pneumoniae, Enterococcus faecalis, Enterobacter cloacae, E. coli, Serratia marcescens and S. aureus.…”

“…Conducted assays showed that among synthesized derivatives compound 40 showed the best activity against all tested strains (Table 9) (Shyma et al 2013). Zorzi et al (2014) synthesized novel series of 3-acetyl-1,3,4-oxadiazolines, which contained 5-nitrofuran system as substituent and evaluated their activity against Candida spp. Two among synthesized compounds 101 and 102 showed antifungal activity higher (MIC = 8-16 µg/ml) than commonly used itraconazole (MIC ≤ 20 µg/ml) (Fig.…”

Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1

“…Similar results were observed in the biological activity of Schiff bases, consisting of furyl (2i) and nitrofuryl (2j) fragments. Since nitrofurfurals and similar compounds have excellent antibacterial activity [33,34]. It should be emphasized that of the synthesized compounds which showed the highest activity were 4-nitrophenyl e (2b) and 5 nitrofuryl e (2f) derivatives.…”

Synthesis, <i>in Vitro</i> and <i>in Silico</i> Studies of Some Novel 5-Nitrofuran-2-yl Hydrazones as Antimicrobial and Antitubercular Agents

“…14) Although, some of the nitrofurans are not therapeutically employed due to their side effects, 15) there is a resurgence of interest in the in evaluation of novel nitroheterocycles as antimicrobials. 14,[16][17][18][19][20] Recently, several studies pointed out the importance of thiophene based derivatives as antibacterial agents. [21][22][23] Besides, Epimerox is a thiophene containing compound that prevented the growth of several Gram-positive pathogens.…”