Exploring a route to a selective and sensitive portable system for explosive detection– swab spray ionisation coupled to of high-field assisted waveform ion mobility spectrometry (FAIMS)

Costa, Catia; Es, E.M. van; Sears, Patrick; Bunch, Josephine; Palitsin, Vladimir; Cooper, Helen J.; Bailey, Melanie J.

doi:10.1016/j.fsisyn.2019.07.009

Cited by 7 publications

(9 citation statements)

References 42 publications

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“…Most nascent CRM ions retain native-like conformations. For unfolded proteins, ESI likely proceeds along routes that are different from the native state mechanism explored here. ,, These foundational studies by Mason and co-workers showed the reproducibility of ion mobility measurements, which enabled the development of standard reference measurements of the mobilities of ions in different gases, a process that continues in the present day. ,,− This robustness of the measurement and the relatively cheap construction costs were influential in the widespread uptake of ion mobility spectrometry as a standalone analytical tool with relevance for environmental monitoring, security, − and healthcare applications. − The concept of reduced mobility ( K 0 ) was also introduced to assist standardization and comparability wherein the temperature and pressure of the gas under investigation are normalized allowed measurements to be compared and instruments to be calibrated. , …”

Section: Historical Development Of Im-msmentioning

confidence: 90%

“…This modified Q-ToF was tested on high-mass and highcomplexity macromolecules, including chaperone complexes (GroEL). 14 Following these findings, it was clear that interest in and opportunities for studying heavier and more complex macromolecules with mass spectrometry was on the rise. In 2013, Snijder et al were the first to report mass spectra with resolved charge-states for a 18 MDa capsid, Prohead-1 gp5 , which consists of a mixture of pentameric and hexameric capsomers and copies of the viral protease gp5.…”

Section: Historical Development Of Im-msmentioning

confidence: 99%

“…Lastly, they tuned the pusher with a lower repetition rate (410 μs) to increase the mass range. This modified Q-ToF was tested on high-mass and high-complexity macromolecules, including chaperone complexes (GroEL) …”

Section: Historical Development Of Im-msmentioning

confidence: 99%

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Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section

Christofi

Barran

2023

Chem. Rev.

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The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-MS) techniques has provided substantial insights into the field of structural biology over the past two decades. An IM-MS workflow applied to a given target analyte provides mass, charge, and conformation, and all three of these can be used to discern structural information. While mass and charge are determined in mass spectrometry (MS), it is the addition of ion mobility that enables the separation of isomeric and isobaric ions and the direct elucidation of conformation, which has reaped huge benefits for structural biology. In this review, where we focus on the analysis of proteins and their complexes, we outline the typical features of an IM-MS experiment from the preparation of samples, the creation of ions, and their separation in different mobility and mass spectrometers. We describe the interpretation of ion mobility data in terms of protein conformation and how the data can be compared with data from other sources with the use of computational tools. The benefit of coupling mobility analysis to activation via collisions with gas or surfaces or photons photoactivation is detailed with reference to recent examples. And finally, we focus on insights afforded by IM-MS experiments when applied to the study of conformationally dynamic and intrinsically disordered proteins.

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Section: Historical Development Of Im-msmentioning

confidence: 90%

Section: Historical Development Of Im-msmentioning

confidence: 99%

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Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section

Christofi

Barran

2023

Chem. Rev.

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“…The formed droplets, containing ions of the analyte, travel through the air, undergoing desolvation before entering a mass spectrometer. [1][2][3][4] Paper spray has been used qualitatively and quantitatively in many application areas from biological matrix analysis, [4][5][6][7][8][9][10][11][12][13][14][15] to foodstuff analysis, [16][17][18][19][20][21][22][23] explosives [24][25][26][27] and warfare agents. 28,29 Most recently, our group has reported the application of paper spray for the rapid detection of drugs of abuse in fingerprints 30,31 and explosives on swabs.…”

Section: Introductionmentioning

confidence: 99%

“…28,29 Most recently, our group has reported the application of paper spray for the rapid detection of drugs of abuse in fingerprints 30,31 and explosives on swabs. 24,25 Despite the growing number of applications relating to paper spray, little consideration has been given to the extraction efficiency of the technique. Some studies have, however, explored the possibility of repeat analysis using paper spray.…”

Section: Introductionmentioning

confidence: 99%

Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two‐step process

Costa

Frampas

Longman

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale Paper spray offers a rapid screening test without the need for sample preparation. The incomplete extraction of paper spray allows for further testing using more robust, selective and sensitive techniques such as liquid chromatography/mass spectrometry (LC/MS). Here we develop a two‐step process of paper spray followed by LC/MS to (1) rapidly screen a large number of samples and (2) confirm any disputed results. This demonstrates the applicability for testing medication adherence from a fingerprint. Methods Following paper spray analysis, drugs of abuse samples were analysed using LC/MS. All analyses were completed using a Q Exactive™ Plus Orbitrap™ mass spectrometer. This two‐step procedure was applied to fingerprints collected from patients on a maintained dose of the antipsychotic drug quetiapine. Results The extraction efficiency of paper spray for two drugs of abuse and metabolites was found to be between 15 and 35% (analyte dependent). For short acquisition times, the extraction efficiency was found to vary between replicates by less than 30%, enabling subsequent analysis by LC/MS. This two‐step process was then applied to fingerprints collected from two patients taking the antipsychotic drug quetiapine, which demonstrates how a negative screening result from paper spray can be resolved using LC/MS. Conclusions We have shown for the first time the sequential analysis of the same sample using paper spray and LC/MS, as well as the detection of an antipsychotic drug from a fingerprint. We propose that this workflow may also be applied to any type of sample compatible with paper spray, and will be especially convenient where only one sample is available for analysis.

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Test method for vapor collection and ion mobility detection of explosives with low vapor pressure

Son,

Choi,

Choi

2023

Rapid Comm Mass Spectrometry

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RationaleIon mobility spectrometry (IMS) has been widely used for on‐site detection of explosives. Air sampling method is applicable only when the concentration of explosive vapor is considerably high in the air, but vapor pressures of common explosives such as 2,4,6‐trinitrotoluene (TNT), 1,3,5‐trinitro‐1,3,5‐triazacyclohexane (RDX), and pentaerythritol tetranitrate (PETN) are very low. A test method for analyzing the vapor detection efficiency of explosives with low vapor pressure via IMS was developed using artificial vapor and collection matrices.MethodsArtificial explosive vapor was produced by spraying an explosive solution in acetone. Fifteen collection matrices of various materials with woven or nonwoven structures were tested. Two arrangements of horizontal and vertical positions of the collection matrices were employed. Explosive vapor collected in the matrix was analyzed using IMS.ResultsOnly three collection matrices of stainless steel mesh (SSM), polytetrafluoroethylene sheet (PFS), and lens cleansing paper (LCP) showed the TNT and/or RDX ion peaks at an explosive vapor concentration of 49 ng/L. There was no collection matrix to detect PETN vapor at or lower than 49 ng/L. For the PFS, TNT and RDX were detected at a vapor concentration of 49 ng/L. For the LCP, TNT and RDX were detected at vapor concentrations of 14 and 49 ng/L, irrespectively.ConclusionsThe difference in the explosive vapor detection efficiencies could be explained by the adsorption and desorption capabilities of the collection matrices. The proposed method can be used for evaluating the vapor detection efficiency of hazardous materials with low vapor pressure.

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Exploring a route to a selective and sensitive portable system for explosive detection– swab spray ionisation coupled to of high-field assisted waveform ion mobility spectrometry (FAIMS)

Cited by 7 publications

References 42 publications

Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section

Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section

Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two‐step process

Test method for vapor collection and ion mobility detection of explosives with low vapor pressure

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