Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Ahmad, Saheem; Ahmad, Mohammad Faizan Ali; Khan, Saif; Alouffi, Sultan; Khan, Mahvish; Prakash, Chander; Khan, Mohd Wajid Ali; Ansari, Irfan Ahmad

doi:10.1016/j.ijbiomac.2024.135761

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.135761

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Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Saheem Ahmad,

Mohammad Faizan Ali Ahmad,

Saif Khan

et al.

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2024

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Cited by 2 publications

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Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Shan,

Cao,

2024

IJGM

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Diabetic kidney disease (DKD) is a form of kidney damage resulting from diabetes and represents a common, severe complication of the disease. Globally, DKD is a leading cause of chronic kidney disease (CKD). DKD occurs in both type 1 and type 2 diabetes patients, with early clinical manifestations including microalbuminuria and hypertension. As the condition progresses, symptoms such as massive proteinuria, hypoalbuminemia, and severe edema may appear. The key to treating DKD lies in controlling blood glucose and blood pressure, reducing proteinuria, and slowing the deterioration of kidney function. Acupuncture, a traditional Chinese medicine treatment, has shown some therapeutic effects on DKD through mechanisms such as regulating blood glucose, improving renal blood flow and microcirculation, antioxidation and anti-inflammation, and modulating gut microbiota.

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Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Shan,

Cao,

2024

IJGM

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The Relationship Between Hand Abnormalities and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

Uzun,

Fındık,

Kaim

et al. 2024

JCM

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Background: The link between diabetes mellitus (DM) and pathological conditions of the hand has been previously investigated. Retinopathy is one of the most common microvascular complications of DM. In this study, we aimed to evaluate the relationship between hand abnormalities and retinopathy in patients with type 2 DM. Methods: Patients with type 2 DM were assessed for hand abnormalities using tactile, functional, and sensory tests. The patients were evaluated electrodiagnostically for carpal tunnel syndrome and polyneuropathy (PNP). A comprehensive ophthalmologic examination was performed to diagnose diabetic retinopathy (DR). Subjective disability and quality of life were evaluated using the Quick DASH questionnaire. The duration of the disease and HbA1c levels were noted. Results: A total of 60 patients with type 2 DM (32 female, 28 male) were recruited for this study. The mean age was 55.1 ± 5.6 years. Among the 60 diabetic patients examined, 15 (25%) were diagnosed with DR. The mean duration of DM was 86.86 ± 51.69 months in patients without DR and 144.75 ± 82.96 months in patients with DR. The mean HbA1c level was 8.86% in the DR group and 8.64% in the non-DR group. PNP was the only hand abnormality that showed a significant association with retinopathy (p = 0.011). Conclusions: PNP might be used as a clue to the presence of retinopathy, especially in long-lasting diabetes. Particular attention should be given to hand abnormalities, especially in patients with PNP, due to their association with DR.

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Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Cited by 2 publications

References 189 publications

Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

The Relationship Between Hand Abnormalities and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

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