Exploring Antiurolithic Effects of Gokshuradi Polyherbal Ayurvedic Formulation in Ethylene-Glycol-Induced Urolithic Rats

Shirfule, Amol L.; Racharla, Venkatesh; Qadri, Syed S.Y.H.; Khandare, Arjun L.

doi:10.1155/2013/763720

Cited by 21 publications

(20 citation statements)

References 25 publications

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“…A significant decrease in SOD and CAT activity in kidney homogenate was observed in lithiatic rats. Similar results have been reported previously [39][40][41].…”

Section: Discussionsupporting

confidence: 93%

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Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Kyada¹,

Mansuri²,

Patel³

2017

J Intercult Ethnopharmacol

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Aim: Antiurolithiatic activity of magnesium lactate gluconate (MLG) and aqueous extract of Garcinia cambogia (GC) fruit was studied. Materials and Methods: The study was performed during December 2016 to April 2017. Urolithiasis was induced in male Wistar rats by administration of 0.75% v/v ethylene glycol for 21 days. From 8 th day onward, intervention with MLG (200 and 400 mg/kg b.w.) and GC (100 and 200 mg/kg b.w.) was started. At the end of the treatment period, biochemical parameters affecting renal stone formation were estimated in the serum, urine, kidney homogenate, and histopathology of harvested kidneys was performed. Results: From in vivo evaluation, it was observed that MLG 400 mg/kg b.w., GC 100 mg/kg b.w., and GC 200 mg/kg b.w. significantly reduced nitrogenous waste products in serum (blood urea nitrogen, creatinine, and uric acid) as well as calculogenic promoters in urine (phosphate and oxalate) and kidney homogenate (calcium, phosphate, and oxalate) when compared to disease control animals. The MLG 200 and MLG 400 were ineffective in restoring superoxide dismutase (SOD) and catalase (CAT) enzyme activity, whereas GC 100, GC 200, and Cystone ® 400 mg/kg b.w. significantly elevated SOD and CAT enzymes in urolithiatic rat kidney. Conclusions: MLG and GC extracts are capable of preventing calcium oxalate (CaOx) crystal formation and subsequent deposition in renal tubules. The principle mechanism underlying nephroprotective effect of test drugs might be attributed to their calcium ion chelating ability and CaOx crystallization inhibitory activity. It is further asserted that GC was more potent than MLG in overall kidney protection by virtue of its antioxidant potential.

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“…A significant decrease in SOD and CAT activity in kidney homogenate was observed in lithiatic rats. Similar results have been reported previously [39][40][41].…”

Section: Discussionsupporting

confidence: 93%

“…A significant increase in kidney TBARS levels on EG and AC challenge is indicative of excessive ROS generation and subsequent depletion of endogenous antioxidant enzymes [39][40][41]. Accumulation of lipid peroxides may further damage EG-administered rat kidneys.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Kyada¹,

Mansuri²,

Patel³

2017

J Intercult Ethnopharmacol

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“…Urine elements such as phosphate and magnesium were not significantly affected by either urolithiasis or saffron extract treatments which is in agreement with some previous studies (Shirfule et al, 2013[ 29 ]).…”

Section: Discussionsupporting

confidence: 92%

Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats

Amin

Feriz

Hariri

et al. 2015

EXCLI Journal; 14:Doc411; ISSN 1611-2156

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“…This fraction was chiefly composed of flavonoids and phenolic compounds as evidenced from phytochemical screening. Flavonoids and phenolics chiefly exhibit antioxidant activity and hence, can serve as antiurolithiatic agents by averting the crystal adhesion and consecutive formation of urinary stones by alleviating the injury caused by crystal accumulation in the urinary system that otherwise enhances the formation of free radicals resulting in destruction of membrane surface of kidney tubules via lipid peroxidation [40,41] . In the present research, the extract and the flavonoid enriched fraction of aerial parts exerted a better efficacy in comparison to those from roots, which is likely attributed to the existence of highly efficacious antiurolithiatic moieties in aerial parts compared to roots.…”

Section: Resultsmentioning

confidence: 99%

In vitro Inhibition of Calcium Oxalate Nucleation by Extract-based Fractions of Aerial Parts and Roots of Aerva lanata (Linn.) Juss. ex Schult

Mandal¹,

Madan²,

Ahmad³

2017

pharmaceutical-sciences

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The current investigation is an attempt to explore the comparative in vitro antiurolithic potential of various phytoconstituent-rich fractions derived from the hydroalcoholic extract of aerial parts and roots of Aerva lanata (Linn.) Juss. ex Schult (Amaranthaceae). The antiurolithic assay was performed by nucleation method. The analysis revealed the phenolic and flavonoid containing fraction from aerial parts to be the most active (71.01±1.13 %) amongst the different extract-derived fractions compared to the one obtained from roots (54.61±2.30 %). Besides, fluorescence analysis and physicochemical evaluation were carried out according to the official guidelines and supported the quality control of the plant material. Preliminary phytochemical screening of the fractions was also performed and confirmed the presence of various metabolites. Additionally, the content of tannins, total phenolics and flavonoids were also determined spectrophotometrically and found to be comparatively higher in aerial parts (tannin content of 4.34±0.63 mg tannic acid equivalent/g extract, total phenolic content of 127.84±1.50 gallic acid equivalent/g extract and total flavonoid content of 77.61±3.78 rutin equivalent/g extract) than roots (tannin content of 3.03±0.63 mg tannic acid equivalent/g extract, total phenolic content of 98.09±1.10 gallic acid equivalent/g extract and total flavonoid content of 62.81±5.69 rutin equivalent/g extract). Hence, the present study aids in screening out the best active extract derived fraction exerting litholytic efficacy, which provides a route to further isolation of lead bioactive compounds contributing to significant antiurolithic potency of this traditionally employed herb of immense pharmacological spectrum.

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Exploring Antiurolithic Effects of Gokshuradi Polyherbal Ayurvedic Formulation in Ethylene-Glycol-Induced Urolithic Rats

Cited by 21 publications

References 25 publications

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats

In vitro Inhibition of Calcium Oxalate Nucleation by Extract-based Fractions of Aerial Parts and Roots of Aerva lanata (Linn.) Juss. ex Schult

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