Excessive food purchases, improper storage, incorrect food preparation, and the disposal of non-expired products contribute significantly to household food waste. Food and nutritional literacy can, therefore, be linked to household food waste and not just to diet quality. Consumers with high food literacy appear to better organize their food shopping and waste less than people with low food literacy. Different studies have demonstrated the association between high nutritional literacy, healthy eating habits, and a high amount of food waste, represented by highly perishable products. The relationship between a high-quality diet and food waste is mainly attributable to the consumption of fruit and vegetables, while an unhealthy diet is associated with fewer leftovers due to the high consumption of ultra-processed foods with a long shelf life. Social and economic conditions influence the effects of literacy on the production of domestic food waste. Many studies have reported that low-income individuals rarely waste food, while richer ones tend to produce more leftovers. The challenge for the scientific, educational, and health policy sectors is to promote the consumption of fresh, healthy, and inexpensive foods, especially in the most disadvantaged segments of the population, and at the same time, provide the knowledge necessary to limit the production of household waste.