Exploring brain functions in autism spectrum disorder: A systematic review on functional near-infrared spectroscopy (fNIRS) studies

Zhang, Fen; Roeyers, Herbert

doi:10.1016/j.ijpsycho.2019.01.003

Cited by 63 publications

(55 citation statements)

References 88 publications

(126 reference statements)

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“…From the neural perspective, the heterogenous behavioral traits of ASD are not thought to stem from specific regions of the brain, but rather from atypical connectivity between brain regions. Atypical connectivity has been identified in numerous studies across multiple brain networks in ASD using various neuroimaging methods, including structural and functional MRI, EEG and MEG, and fNIRS (for reviews, see Hull et al, 2017;O'Reilly, Lewis, & Elsabbagh, 2017;Rane et al, 2015;Zhang & Roeyers, 2019). Although the findings of altered connectivity in ASD are vast, one finding that is particularly relevant to the current design is that Inflexibility of neural circuitry has been linked to behavioral inflexibility in ASD.…”

Section: Changepoint Oddballmentioning

confidence: 98%

The stability flexibility tradeoff and the dark side of detail

Nassar

Troiani

2020

Preprint

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Acknowledgments:We thank Ben Heasly for programming the original version of our task. We also thank Antoinette Sabatino DiCriscio and Kayleigh Adamson for assistance with participant testing. This work was supported by a Simons Foundation SFARI Explorer Award (#350225) to V.T. and NIH F32-MH102009-01A1 and K99AG054732 to M.R.N. AbstractLearning in dynamic environments requires integrating over stable fluctuations to minimize the impact of noise (stability) but rapidly responding in the face of fundamental changes (flexibility). Achieving one of these goals often requires sacrificing the other to some degree, producing a stability-flexibility tradeoff. Individuals navigate this tradeoff in different ways, with some people learning rapidly (emphasizing flexibility) and others relying more heavily on historical information (emphasizing stability). Despite the prominence of such individual differences in learning tasks, the degree to which they relate to broader characteristics of real-world behavior or pathologies has not been well explored.Here we relate individual differences in learning behavior to self-report measures thought to collectively capture characteristics of the Autism spectrum. We show that that young adults who learn most slowly tend to integrate more effective samples into their beliefs about the world making them more robust to noise (more stability), but are more likely to integrate information from previous contexts (less flexibility). We show that individuals who report paying more attention to detail tend to use high flexibility and low stability information processing strategies. We demonstrate the robustness of this inverse relationship between attention to detail and formation of stable beliefs in a heterogeneous population of children that includes a high proportion of Autism diagnoses. Together, our results highlight that attention to detail reflects an information processing policy that comes with a substantial downside, namely the ability to integrate data to overcome environmental noise.

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Section: Changepoint Oddballmentioning

confidence: 98%

The stability flexibility tradeoff and the dark side of detail

Nassar

Troiani

2020

Preprint

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“…In the past two decades, functional near-infrared spectroscopy (fNIRS) has emerged as a promising tool to detect NVC in human subjects, first mainly used as a proxy measure for neuronal activation. In this context, fNIRS has been used in several studies related to autism (Zhang and Roeyers 2019), pediatric studies (Bortfeld 2019), and psychiatry (Ehlis et al 2014;Grazioli et al 2019). In the present review, we discuss the potential use of fNIRS-based methods to study NVC responses in translational geroscience research.…”

Section: Physiology Of Neurovascular Couplingmentioning

confidence: 99%

Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans

et al. 2019

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Preclinical studies provide strong evidence that age-related impairment of neurovascular coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment (VCI). NVC is a critical homeostatic mechanism in the brain, responsible for adjustment of local cerebral blood flow to the energetic needs of the active neuronal tissue. Recent progress in geroscience has led to the identification of critical cellular and molecular mechanisms involved in neurovascular aging, identifying these pathways as targets for intervention. In order to translate the preclinical findings to humans, there is a need to assess NVC in

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“…Complex behavioral abnormalities in ASD are difficult to explain solely by dysfunction of a specific brain area. Malformations in the cytoarchitectonic cerebral cortex (7,24) and dysfunction in cortical circuits (32,44) are the most commonly observed findings in autopsied brains and in clinical studies of patients with ASD. After the last radial maze learning trial of this study, the density of c-Fos-positive cells in the prefrontal cortex (PrL, VO and LO), which correlates with neural activity, was clearly reduced, but not in the barrel filed of the primary sensory cortex (S1BF) and secondary somatosensory cortex (S2) of E14-VPA mice compared with controls ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Exposure to valproic acid during middle to late-stage corticogenesis induces learning and social behavioral abnormalities with attention deficit/hyperactivity in adult mice

et al. 2019

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Single prenatal exposure to valproic acid (VPA) in rodents is a widely used preclinical model of autism spectrum disorder (ASD). Continuous prenatal VPA exposure has been recently proposed as a new ASD model that closely captures the neuropathological features of ASD, including increases in cerebral cortex volume and the number of cortical upper layer neurons. We investigated the influence of prenatal VPA exposure on the behavior of adult offspring of pregnant dams that received intraperitoneal injections of VPA twice on one day during the genesis of cortical upper layer neurons. Mice exposed to VPA at E14 (E14-VPA) showed typical behavior abnormalities including reduced social interaction, hyperactivity, and poor maze learning due to attention deficit/ impulsivity relative to healthy controls. Histological analysis revealed that E14-VPA mice had significantly increased neuronal density and impaired neural activity in the prefrontal cortex, but not the somatosensory area, which is likely linked to the observed abnormalities in social behavior. These results suggest that this VPA exposure method is a good model for gaining new insights into the underlying neuropathology of ASD.

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Exploring brain functions in autism spectrum disorder: A systematic review on functional near-infrared spectroscopy (fNIRS) studies

Cited by 63 publications

References 88 publications

The stability flexibility tradeoff and the dark side of detail

The stability flexibility tradeoff and the dark side of detail

Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans

Exposure to valproic acid during middle to late-stage corticogenesis induces learning and social behavioral abnormalities with attention deficit/hyperactivity in adult mice

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