Exploring cartilage damage in gout using 3-T MRI: distribution and associations with joint inflammation and tophus deposition

Popovich, I.; Dalbeth, Nicola; Doyle, Anthony; Reeves, Quentin; McQueen, Fiona

doi:10.1007/s00256-014-1869-7

Cited by 26 publications

(28 citation statements)

References 25 publications

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“…Analysis of MRI scans has shown that cartilage damage is predominantly focal and closely related to sites of tophus deposition [49]. In this same study, bone erosions were associated with cartilage destruction, and tophus infiltration into bone was accompanied by damage to the overlying cartilage.…”

Section: Structural Consequences Of Tophaceous Goutmentioning

confidence: 80%

The Gouty Tophus: a Review

2015

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The tophus is the cardinal feature of advanced gout. This review summarises recent research into the biology, impact and treatment of tophaceous gout. Microscopically, tophi are chronic foreign body granuloma-like structures containing collections of monosodium urate (MSU) crystals surrounded by inflammatory cells and connective tissue. Extracellular trap formation mediated by neutrophil interactions with MSU crystals may be a central checkpoint in tophus formation. Gouty tophi impact on many aspects of health-related quality of life. Tophi are also implicated in the development of structural joint damage and increased mortality risk in people with gout. Effective treatment of tophaceous gout requires long-term urate-lowering therapy, ideally to achieve a serum urate concentration of <5 mg/dL (300 μmol/L). Recent advances in gout therapeutics have expanded urate-lowering therapy options for patients with severe tophaceous disease to allow faster regression of tophi, improved health-related quality of life and, potentially, improved structural outcomes.

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Section: Structural Consequences Of Tophaceous Goutmentioning

confidence: 80%

The Gouty Tophus: a Review

2015

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“…We recently developed an MRI scoring system to assess cartilage damage at the wrist in gout . Although the wrist is not a typical clinical site for acute gout attacks, we have found a high level of clinical and subclinical involvement in the Maori and Pacific Island patients who present frequently to rheumatology clinics in Auckland, New Zealand and have severe, disabling gout .…”

Section: Introductionmentioning

confidence: 97%

A comparative MRI study of cartilage damage in gout versus rheumatoid arthritis

et al. 2015

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Cartilage damage is less severe in gout than in RA, with fewer sites affected and lower overall scores. It is associated with synovitis in both diseases, likely indicating an effect of pro-inflammatory cytokine production on cartilage integrity. However, the strong association between cartilage damage and BME observed in RA was not identified in gout. This emphasizes differences in the underlying pathophysiology of joint damage in these two conditions.

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“…Molecular imaging can provide molecular information on the underlying biochemical and inflammatory processes, that is complementary to anatomical imaging. Development of metal plasmonic nanoparticles for MRI25 allows using MRI also for molecular imaging in addition to its use for anatomical imaging. Other molecular probes being developed for molecular arthritis imaging include fluorescence and near-infrared labelled probes26 for optical imaging or radioisotopes labelled probes for scintigraphy, PET or SPECT14.…”

Section: Discussionmentioning

confidence: 99%

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies

Zheng

Perlman

Matthys

et al. 2016

Sci Rep

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Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further addressed the specificity and assessed the potential for arthritis monitoring. Signals obtained with 99mTc-labelled NbV4m119 Nanobody were compared in joints of wild type (WT) versus CRIg−/− mice with collagen-induced arthritis (CIA) or K/BxN serum transfer-induced arthritis (STIA). In addition, SPECT/μCT imaging was used to investigate arthritis development in STIA and in CIA under dexamethasone treatment. 99mTc-NbV4m119 accumulated in inflamed joints of WT, but not CRIg−/− mice with CIA and STIA. Development and spontaneous recovery of symptoms in STIA was reflected in initially increased and subsequently reduced joint accumulation of 99mTc-NbV4m119. Dexamethasone treatment of CIA mice reduced 99mTc-NbV4m119 accumulation as compared to saline control in most joints except knees. SPECT/μCT imaging with 99mTc-NbV4m119 allows specific assessment of inflammation in different arthritis models and provides complementary information to clinical scoring for quantitatively and non-invasively monitoring the pathological process and the efficacy of arthritis treatment.

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Exploring cartilage damage in gout using 3-T MRI: distribution and associations with joint inflammation and tophus deposition

Abstract: Magnetic resonance imaging can be used to investigate cartilage in gout. Cartilage damage was relatively uncommon, focal, and associated with bone erosions, tophi and synovitis, but not bone oedema. This emphasises the unique pathophysiology of gout.

Cited by 26 publications

References 25 publications

The Gouty Tophus: a Review

The Gouty Tophus: a Review

A comparative MRI study of cartilage damage in gout versus rheumatoid arthritis

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies

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