Exploring causal relationships between inflammatory cytokines and allergic rhinitis, chronic rhinosinusitis, and nasal polyps: a Mendelian randomization study

Li, Li; Zhang, Yuanding; Liu, Hong; Wang, Tianqi; Li, Junxin; Wang, Xin

doi:10.3389/fimmu.2023.1288517

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Using the example of patients with Sjögren's disease, it was shown that HMGB1, together with TNF-α and IL-1β, can form a pro-inflammatory loop that contributes to chronic inflammation of the nasal mucosa and paranasal sinuses [38]. A positive correlation was also shown between increased levels of circulating TNF-α and an increased risk of developing allergic rhinitis (OR = 1.01478, 95% CI = 1.00225-1.02746, p = 0.02067), that is, the presence of a cause-and-effect relationship [39]. These results are consistent with our findings.…”

Section: Discussionmentioning

confidence: 97%

Production of the Proinflammatory Cytokine TNF-α in Patients with Chronic Epstein-Barr Virus Infection

IA,

2024

J Viro Res Rep

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Aim of the Study: Study of the production of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) in patients with Chronic Epstein-Barr Viral Infection (CEBI). Material and Methods: 90 patients with CVEBI were examined. The group consisted of 66 women and 24 men. The average age of the patients was 38.37 ± 1.15 years. The duration of the course of CVEBI from the appearance of the patient’s first complaints to diagnosis was 3.73 ± 0.22 years. The amount of EBV DNA in saliva samples (PCR method) and the level of production of the cytokine TNF-α ware examined in patients. Results: The copy number of EBV DNA in saliva samples from patients was 135898.61±23196.21 cop/ml. The level of induced TNF-α in the general group was 3288.73±260.88. All patients were divided into three groups: group 1 (n = 49) - the level of induced TNF-α was reduced - 1624.69±105.53 (pg/ ml) (95% CI: 1412.52; 1836.86) ; Group 2 (n =30) - the level of induced TNF-α is normal - 3819.19 ±427.00 (pg/ml) (95% CI: 3045.27; 4701.81); Group 3 (n =11) the level of induced TNF-α is high – 7203.00 ± 627.50 (pg/ml) (95% CI: 6135.37 - 8609.87). Patients did not differ in age, disease duration, or number of EBV DNA copies in saliva samples. The linear and exponential regression method was used to show the effect of disease duration on the level of TNF-α production in the general group of patients (R2 =0.386 F=55.925 p=0.0001 β=0.621 and R2 =0.735 F=246.808 p=0.0001 β=0.857, respectively). TNF-α influences the development of headaches in patients (Pearson correlation R = 0.223 p = 0.040) and the severity of postnasal drip (r = -0.231 p = 0.033 τ = - 0.171 p = 0.039). Conclusion: The study showed that the duration of the disease affects the level of production of induced TNF-α. TNF-α levels contribute to the development of headaches and postnasal drip in patients in the general group.

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Section: Discussionmentioning

confidence: 97%

Production of the Proinflammatory Cytokine TNF-α in Patients with Chronic Epstein-Barr Virus Infection

IA,

2024

J Viro Res Rep

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A personalized approach to medical rehabilitation for patients with rhinosinusitis with nasal polyps and comorbid asthma

Pelishenko,

Kruglova,

Nagornev

et al. 2024

Russian Journal of Physiotherapy, Balneology and Rehabilitation

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BACKGROUND: Personalized medical rehabilitation options are required for patients with chronic rhinosinusitis with nasal polyps owning to the relatively high prevalence of this disease, its long and often uncontrolled course, and the significant decrease in quality of life of patients. Comorbid asthma is common in patients with rhinosinusitis with nasal polyps and is associated with more severe clinical manifestations and increased unresponsiveness to therapy, reducing the effectiveness of rehabilitation efforts. AIM: The aim of the study was to identify predictors of personalized comprehensive rehabilitation options to be used in patients with rhinosinusitis with nasal polyps and comorbid asthma in order to achieve greater clinical effectiveness of therapy and control of nasal polyps. MATERIALS AND METHODS: The study was conducted in 35 patients with rhinosinusitis with nasal polyps and comorbid asthma. Comprehensive medical rehabilitation included endonasal use of Nasonex 2 doses twice daily; nasal rinsing twice daily; subcutaneous use of dupilumab at 300 µg every 2 weeks; use of low-dose inhaled corticosteroid (beclomethasone dipropionate at 200 µg twice daily); a course of alternating magnetic field therapy, low-intensity laser radiation, and interval hypoxic training. At baseline, nasal polyp severity, respiratory function, quality of life, and levels of cytokines, immunoglobulins, leukocytes, lymphocytes, and eosinophils were assessed. The effectiveness of rehabilitation measures was assessed 6 months after the start of treatment using the International Classification of Functioning, Disability, and Health criteria. RESULTS: Using multiple regression analysis, an information model was developed to predict effectiveness of comprehensive medical rehabilitation in patients with rhinosinusitis with nasal polyps and comorbid asthma. The resulting attribute of the model was the final score of the seven selected domains of the International Classification of Functioning, Disability, and Health. A cluster of baseline clinical and laboratory variables was identified as predictors, including blood eosinophil level, blood tumor necrosis factor-alpha (TNF-alpha) level, total score for a 22-item Sino-Nasal Outcome Test (SNOT-22) functional domain, and forced expiratory volume in one second. Higher level of rehabilitation was achieved with the following baseline characteristics: blood eosinophil counts no more than 0.85 × 109/L; blood TNF-α level no more than 18.0 pg/mL; total score for the SNOT-22 functional domain no more than 8; forced expiratory volume in one second no less than 2.6 L. CONCLUSION: At baseline, the identified thresholds of the selected predictors predict the outcome that could be achieved for each patient who receives personalized comprehensive rehabilitation.

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Mutual Influence Between Allergic Rhinitis and Sleep: Factors, Mechanisms, and interventions—A Narrative Review

Yang,

Wang,

Mou

et al. 2024

NSS

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Patients with allergic rhinitis (AR) have a high incidence of sleep disorders, such as insomnia, which can easily exacerbate nasal symptoms. The aggravation of nasal symptoms further promotes the deterioration of sleep disorders, forming a vicious cycle. Severe cases may even trigger psychological and neurological issues, such as anxiety, depression, and cognitive impairment, causing significant distress to patients, making clinical diagnosis and treatment difficult, and increasing costs. Furthermore, satisfactory therapeutics remain lacking. As the pathogenesis of AR-associated sleep disorders is not clear and research is still insufficient, paying attention to and understanding AR-related sleep disorders is crucial in clinical practice. Multiple studies have shown that the most crucial issues in current research on AR and sleep are analyzing the relationship between AR and sleep disorders, searching for the influencing factors, and investigating potential targets for diagnosis and treatment. This review aimed to identify and summarize the results of relevant studies using “AR” and “sleep disorders” as search terms. In addition, we evaluated the correlation between AR and sleep disorders and examined their interaction and potential mechanisms, offering a foundation for additional screening of potential diagnostic biomarkers and therapeutic targets.

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Exploring causal relationships between inflammatory cytokines and allergic rhinitis, chronic rhinosinusitis, and nasal polyps: a Mendelian randomization study

Cited by 4 publications

References 40 publications

Production of the Proinflammatory Cytokine TNF-α in Patients with Chronic Epstein-Barr Virus Infection

Production of the Proinflammatory Cytokine TNF-α in Patients with Chronic Epstein-Barr Virus Infection

A personalized approach to medical rehabilitation for patients with rhinosinusitis with nasal polyps and comorbid asthma

Mutual Influence Between Allergic Rhinitis and Sleep: Factors, Mechanisms, and interventions—A Narrative Review

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