Exploring Coumarin and Chalcone Analogues as Potential Antimycobacterial Agents

Shukla, Shefali; Gahlot, Pragya; Khandekar, Ameya; Agrawal, Arush; Pasricha, Sharda

doi:10.2174/2211352515666171120142559

Cited by 3 publications

(5 citation statements)

References 62 publications

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“…In order to evaluate the antioxidant activity of synthesized compounds, we use three antioxidant assays: DPPH radical inhibition, total reducing power, and nitric oxide (NO) inhibition. The studied coumarin hydrazide derivatives were the most potent DPPH free radical scavengers (13,14,15,16) with an inhibitory percentage of over 90%, 15's activities were comparable to those of the standard, and the addition of sulphur atoms to the molecule had a favourable impact on its scavenging potential. Compared to their analogues with propyl radical, compounds IIIa and IVa with a methyl group were a little bit more active.…”

Section: Antioxidant Activitymentioning

confidence: 92%

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Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review

Shaji¹,

Nair²,

Dharan³

2022

Int J Res Rev

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Coumarins are heterocyclic compound with a benzopyrone structure. Coumarins are a large group of organic compounds found in several plants even in bacteria and fungi. The biological activities of coumarins and its derivatives includes anticoagulant, anticancer, antiulcer, antifungal, anti-HIV, antimicrobial, antiosteoporosis, antioxidant and anti- inflammatory activity. Hydrazide-hydrazone derivatives act as structural sub units in many pharmacologically active compounds including coumarins to give biological activities like antimicrobial, anticancer, antifungal, anti-inflammatory, antiviral, anti-tubercular, and antiprotozoal activity. The interest in the synthesis of coumarin derivatives has been gaining importance over the last decades, reflecting the importance of such compounds in both medical and chemical research. In this review hydrazide-hydrazone derivatives of coumarins are taken into consideration and emphasised on the anticancer, antitubercular, antimicrobial, antioxidant and antidiabetic activity of these derivatives. Keywords: Coumarin, hydrazide, heterocyclic, benzopyran, antitumor, antimicrobial, antioxidant

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Section: Antioxidant Activitymentioning

confidence: 92%

“…Additionally, the derivatives with nitro groups were discovered to be the most active in this class. [16] O…”

Section: Anti-tubercular Activitymentioning

confidence: 99%

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Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review

Shaji¹,

Nair²,

Dharan³

2022

Int J Res Rev

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“…The recent literature on the therapeutic effects of coumarins reveals a range of potential medical applications for these compounds. The studies included the investigation of the pharmacological and biological impacts of coumarins, encompassing anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antimicrobial, and neuroprotective activities [1][2][3][4][5][6][7][8]. This diverse range of activities makes coumarins promising candidates for the development of new therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Coumarin Derivatives: The Influence of Cycloalkyl Groups at the C-3 Position on Intermolecular Interactions—Synthesis, Structure and Spectroscopy

Szwaczko,

Kamiński,

Koziol

2024

Crystals

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In this study, we explore the synthesis and solid-state characterization of four coumarin-3-carboxylic acid esters, each modified at the C-3 position with different cycloalkyl groups: cyclohexyl, menthyl, and iso-pulegyl. We conducted a detailed analysis of these compounds utilizing a variety of techniques such as a single-crystal X-ray diffraction, nuclear magnetic resonance (NMR), and Fourier-transform infrared (FTIR) spectroscopy. Additionally, we calculated the dipole moments for these molecules. Our findings include a thorough structural assessment, highlighting the role of noncovalent interactions through Full Interaction Maps and Hirshfeld surface analysis. This study reveals the critical influence of the weak C-H…O hydrogen bonds in determining the solid-state architecture of these esters, whereas π-π stacking interactions appear to be negligible among the studied derivatives.

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“…Coumarin (Figure 1) is a plant‐derived natural product, and the benzopyrone structure enables its derivatives to readily interact with diverse enzymes and receptors in organisms through weak bond interactions. [ 8–10 ] Therefore, coumarin derivatives possess a variety of pharmacological properties such as anti‐inflammatory, [ 11,12 ] anticancer, [ 13–16 ] anti‐Alzheimer, [ 17,18 ] antimycobacterial, [ 19,20 ] antifungal, [ 21,22 ] antimalarial, [ 23,24 ] antiviral, [ 25,26 ] anticoagulant, [ 27,28 ] and antibacterial activities. [ 29,30 ] The mechanistic study indicated that the antibacterial activity of coumarin derivatives was mainly due to their ability to bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling by blocking the ATPase activity.…”

Section: Introductionmentioning

confidence: 99%

Coumarin‐containing hybrids and their antibacterial activities

Feng

Zhang

Yang

et al. 2020

Archiv der Pharmazie

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Infections caused by Gram-positive and -negative bacteria are one of the foremost causes of morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial infections, but the emergence and wide spread of drug-resistant pathogens have already become a huge issue for public healthcare systems. The coumarin moiety, which is ubiquitous in nature, could bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling by blocking the ATPase activity; hence, coumarin derivatives possess potential antibacterial activity. Several coumarin-containing hybrids such as coumermycin A1, clorobiocin, and novobiocin have already been used in clinical practice for the treatment of various bacterial infections; thus, it is conceivable that hybridization of the coumarin moiety with other antibacterial pharmacophores may provide opportunities for the development of novel antibiotics. This review outlines the advances in coumarin-containing hybrids with antibacterial potential in the recent 5 years and the structure-activity relationships are also discussed. K E Y W O R D S antibacterial, coumarin, hybrid compounds, structure-activity relationships

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Exploring Coumarin and Chalcone Analogues as Potential Antimycobacterial Agents

Cited by 3 publications

References 62 publications

Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review

Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review

Coumarin Derivatives: The Influence of Cycloalkyl Groups at the C-3 Position on Intermolecular Interactions—Synthesis, Structure and Spectroscopy

Coumarin‐containing hybrids and their antibacterial activities

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