Purpose: To test a pharmacist-led intervention to improve gout treatment adherence and outcomes. Methods: We conducted a site-randomized trial (n=1,463 patients) comparing a one-year, pharmacist-led intervention to usual care in gout patients initiating allopurinol. The intervention was delivered primarily through automated telephone technology. Co-primary outcomes were the proportion of patients adherent (proportion of days covered ≥0.8) and achieving a serum urate <6.0 mg/dl at one year. Outcomes were reassessed at year two. Results: Intervention patients were more likely than usual care patients to be adherent (50% vs. 37%; OR 1.68; 95% CI 1.30, 2.17) and reach serum urate goal (30% vs. 15%; OR 2.37; 95% CI 1.83, 3.05). In the second year (one year after the intervention ended), differences were attenuated,