The agricultural supply chain (ASC) in the hinterland refers to the entire post-harvest process of processing and distributing agricultural products in rural or secluded areas to be brought to big city markets. This scheme involves various stakeholders (farmers, trading centers, consumers), processes (logistics, storage, monitoring), and infrastructure (traffic and road systems, negative environmental emissions) to ensure the efficient flow of agricultural products from farms to consumers. The quality of life (QoL) in the hinterland can improve with the introduction of disruptive technologies, but no comprehensive studies have explored the QoL of individuals involved in the ASC–socioeconomic system of hinterland communities. This study elucidated and compared the diversified impacts of disruptive technologies brought by the Industrial Revolution 4.0 to the agricultural supply chain and their impacts on food security, sustainability, and climate change mitigation through the analysis of the related literature. This study also mapped out the role of disruptive technologies in the QoL of hinterland communities, particularly with respect to the farmers, trading center workers, and consumers. Points of discussion emerged with respect to precision agriculture, the Artificially Intelligent Internet of Things, big data analytics, blockchain, artificial intelligence, cyber-physical systems, robotics, automation, and e-commerce, and how these enabling technologies enhance fresh food supply and distribution and deliberately affect stakeholders’ life quality indexes through the analysis of situational case studies in India, South America, Malaysia, China, and Europe. The identification of these points of discussion was also achieved purely based on research performed on the related literature. The positive impacts of these technologies, such as the boosting of efficiency and the ensuring of a steady supply of fresh produce, ultimately improve the overall QoL. The technical insights from the studies were synthesized to develop new frameworks for QoL anchored in the agricultural supply chain (AgQoL) in the hinterland, and a six-dimensional network emphasizing the two trifectas of techno-socioenvironmental needs was established. Food-producing communities with a relatively high AgQoL should support food security in the region.