Exploring Decaprenylphosphoryl-β-d-Ribose 2′-Epimerase 1 (DprE1): A Target for Anti-tubercular Drugs

Yadav, Mange Ram; Murumkar, Prashant R.; Ghuge, Rahul B.; Barot, Rahul R.; Chauhan, Monica

doi:10.1007/978-3-031-15955-8_24

Cited by 4 publications

(2 citation statements)

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“…40 Decaprenol-1-phosphoribose (DPR) production involves multiple enzymatic steps catalyzed by UbiA, PrsA, and DprE1/DprE2. 41 The addition of arabinofuranosyl residues to the AG backbone is catalyzed by arabinofuranosyl transferase (AftA) and Emb proteins (EmbA and EmbB). 5 AG was linked to the PG layer by Lcp1.…”

Section: Potential Targetsmentioning

confidence: 99%

“…Galactose residues are added to the PG linkage by galactofuranosyltransferases (GlfT1 and GlfT2), whereas arabinose residues are provided by decaprenylphosphoryl- d -arabinose (Araf) . Decaprenol-1-phosphoribose (DPR) production involves multiple enzymatic steps catalyzed by UbiA, PrsA, and DprE1/DprE2 . The addition of arabinofuranosyl residues to the AG backbone is catalyzed by arabinofuranosyl transferase (AftA) and Emb proteins (EmbA and EmbB) .…”

Section: Arabinogalactan Biosynthesis and Potential Targetsmentioning

confidence: 99%

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Revolutionizing Tuberculosis Treatment: Uncovering New Drugs and Breakthrough Inhibitors to Combat Drug-Resistant Mycobacterium tuberculosis

Verma,

Naik,

Kumar

et al. 2023

ACS Infect. Dis.

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Tuberculosis (TB) is a global health threat that causes significant mortality. This review explores chemotherapeutics that target essential processes in Mycobacterium tuberculosis, such as DNA replication, protein synthesis, cell wall formation, energy metabolism, and proteolysis. We emphasize the need for new drugs to treat drug-resistant strains and shorten the treatment duration. Emerging targets and promising inhibitors were identified by examining the intricate biology of TB. This review provides an overview of recent developments in the search for anti-TB drugs with a focus on newly validated targets and inhibitors. We aimed to contribute to efforts to combat TB and improve therapeutic outcomes.

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Section: Potential Targetsmentioning

confidence: 99%

Section: Arabinogalactan Biosynthesis and Potential Targetsmentioning

confidence: 99%