Exploring Decision-Making of HIV-Infected Hispanics and African Americans Participating in Clinical Trials

Rivera-Goba, Migdalia V.; Dominguez, Dinora C.; Stoll, Pamela; Grady, Christine; Ramos, Catalina Vargas; Mican, JoAnn M.

doi:10.1016/j.jana.2010.10.007

Cited by 24 publications

(23 citation statements)

References 21 publications

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“…Recent years have seen an increase in the use of community-based participatory research (CBPR) with Latinos [61], and there has been substantial work done on mental health service utilization [62-64], and inclusion and retention in clinical trials among Latinos [65, 66]. However, the current study is the first to adapt an evidence-based intervention for depression and non-adherence in Latinos living with HIV [67].…”

Section: Discussionmentioning

confidence: 99%

A Preliminary RCT of CBT-AD for Adherence and Depression Among HIV-Positive Latinos on the U.S.-Mexico Border: The Nuevo Día Study

et al. 2013

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We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression (CBT-AD) with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of “moderate” to “large” size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = - 3.64, p = .05) and greater adherence according to the electronic pillbox (OR = 3.78, p = .03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

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Section: Discussionmentioning

confidence: 99%

A Preliminary RCT of CBT-AD for Adherence and Depression Among HIV-Positive Latinos on the U.S.-Mexico Border: The Nuevo Día Study

et al. 2013

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“…(11), in the Retrovirus Epidemiology Donor Studies (REDS-I/-II), demonstrated repository participation rates were lower among African-Americans and Hispanics than among non-Hispanic Whites. These studies suggested that Hispanics are less likely to participate in clinical trials and biobanking because they have concerns related to sharing of genetic data and lack of credibility and trust in research institutions (12, 23). Among focus groups, similar concerns have been reported among racial and ethnic minorities (24, 25).…”

Section: Discussionmentioning

confidence: 99%

Association of Acculturation, Nativity, and Years Living in the United States with Biobanking among Individuals of Mexican Descent

López

Fernández

Cano

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Biobanking is the collection of human biospecimens (tissues, blood and body fluids) and their associated clinical and outcome data. Hispanics are less likely to provide biological specimens for biobanking. The purpose of this study was to investigate the association of acculturation, nativity status and years living in the United States with participation in biobanking among individuals of Mexican descent. Methods Participants were 19,212 adults of Mexican descent enrolled in an ongoing population-based cohort in Houston, Texas. Participants were offered the opportunity to provide a blood, urine or saliva sample for biobanking. Acculturation was assessed with the Bidimensional Acculturation Scale for Hispanics and scores were categorized into “low acculturation,” “bicultural,” and “high-acculturation.” Results After multivariable adjustment, we found an increased likelihood of participation in biobanking among individuals classified as “bicultural” as compared with “highly acculturated” individuals (OR=1.58; 95% CI, 1.10–2.26). The associations of nativity status and years living in the United States with biobanking were not statistical significant. After stratifying by gender, the associations of acculturation, nativity status and years living in the U.S. with biobanking were not statistically significant. Conclusion Although individuals of Mexican descent who were “bicultural” were more likely to participate in biobanking than individuals who were “highly acculturated,” the difference in rates of participation among acculturation categories was small. The high participation rate in biospecimen collection is likely due to extensive community-engaged research efforts. Future studies are warranted to understand individuals’ participation in biobanking. Impact Community-engaged research efforts may increase Hispanics’ participation in biobanking.

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“…These include a lack of information about the research process 4,5 and clear descriptions of research benefits, 5 as well as long-standing mistrust of medical and research establishments, 6–17 misconceptions about trials, 18,19 concerns about being used as a guinea pig, 16,20 and low perceived risk of HIV infection. 21 Furthermore, community engagement models have demonstrated the need for capacity building in communities for them to fully engage in research, capacity building that includes information sharing 5,12,16,22–25 and, according to the World Health Organization, teaching knowledge and skills to enable communities to practice effective health promotion. 26 We used participatory approaches to develop knowledge and skills within the community to support engagement in HIV prevention research.…”

mentioning

confidence: 99%

Curriculum Development to Increase Minority Research Literacy for HIV Prevention Research: A CBPR Approach

Isler¹,

Ae²,

Eley³

et al. 2014

cpr

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Background Minority engagement in HIV prevention research can improve the process and products of research. Using community-based participatory research (CBPR) to develop capacity-building tools can promote community awareness of HIV prevention, clinical research, and community roles in research. Objectives We sought to describe a CBPR approach to curriculum development to increase HIV prevention research literacy among Blacks ages 18 to 30. Methods Community members and researchers documented the iterative and participatory nature of curriculum development and lessons learned. Results/Lessons Learned We used specific strategies to support and verify multi-stakeholder engagement, team building, capacity building, and shared decision making. Objective or formal assessments of baseline capacity, ongoing stakeholder engagement, and reinforcing the value of multiple perspectives can promote further equity in curriculum development between researchers and community members. Conclusions The iterative process of shared discussion, development, and consensus building strengthened collaboration between stakeholder groups and produced a stronger, more culturally appropriate curriculum to promote HIV prevention research engagement among young Blacks.

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Exploring Decision-Making of HIV-Infected Hispanics and African Americans Participating in Clinical Trials

Cited by 24 publications

References 21 publications

A Preliminary RCT of CBT-AD for Adherence and Depression Among HIV-Positive Latinos on the U.S.-Mexico Border: The Nuevo Día Study

A Preliminary RCT of CBT-AD for Adherence and Depression Among HIV-Positive Latinos on the U.S.-Mexico Border: The Nuevo Día Study

Association of Acculturation, Nativity, and Years Living in the United States with Biobanking among Individuals of Mexican Descent

Curriculum Development to Increase Minority Research Literacy for HIV Prevention Research: A CBPR Approach

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