Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

Ravindar, Lekkala; Hasbullah, Siti Aishah; Rakesh, K.P.; Raheem, Saki; Agustar, Hani Kartini; Ismail, Norzila; Ling, Lau Yee; Hassan, Nurul Izzaty

doi:10.1016/j.ejmech.2023.116043

Cited by 11 publications

(2 citation statements)

References 111 publications

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“…Quinolines are an important class of heterocycles that are widely represented in natural products, 1 pharmaceuticals, biologically active substances, 2 agrochemicals, 3 functional materials, 4 organocatalysts or ligands, 5 and valuable intermediates. 6 Several quinoline derivatives such as chloroquine and cryptolepine (anti-malarial), 7 ciprofloxacin (antibacterial), 8 topotecan and camptothecin (anticancer), 9 dibucaine (local anesthetic), 10 and bedaquiline (anti-tubercular) 11 are widely used in clinics (Fig.…”

Section: Introductionmentioning

confidence: 99%

Lewis acid-mediated modular route to the synthesis of 3-substituted quinolines from 2-aminobenzyl alcohols and enamine(one)s

Ghosh,

Upadhyay,

Dahatonde

et al. 2024

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

Lewis acid-mediated modular route to the synthesis of 3-substituted quinolines from 2-aminobenzyl alcohols and enamine(one)s

Ghosh,

Upadhyay,

Dahatonde

et al. 2024

New J. Chem.

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“…Additionally, 4-(quinolin-4-yl)morpholine C exhibited some in vitro antibacterial activity [15]. Additionally, pincer palladium complexes, based on the N-(quinolin-8-yl)amide ring, have been widely explored for diverse catalytic transformations [16], and 4,7-dichloroquinoline has been extensively used in drug and functional material research as an affordable chemical intermediate for numerous bioactive functionalized 4-amino-quinoline compounds [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline

Aparicio Acevedo,

Ortiz Villamizar,

Kouznetsov

2024

Molbank

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The quinoline derivative, N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using a N-oxidation reaction/C2-amide formation reaction/C4 SNAr reaction sequence. The structure of the compound was fully characterized by FT-IR, 1H-, 13C-NMR, DEPT-135°, and ESI-MS techniques. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the online SwissADME database. Such derivatives are relevant therapeutic agents exhibiting potent anticancer, antibacterial, antifungal, and antiparasitic properties.

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A survey of isatin hybrids and their biological properties

Shu,

Eni,

Ntie-Kang

2024

Mol Divers

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The emergence of diverse infections worldwide, which is a serious global threat to human existence, necessitates the urgent development of novel therapeutic candidates that can combat these diseases with efficacy. Molecular hybridization has been established as an efficient technique in designing bioactive molecules capable of fighting infections. Isatin, a core nucleus of an array of compounds with diverse biological properties can be modified at different positions leading to the creation of novel drug targets, is an active area of medicinal chemistry. This review containing published articles from 2005 to 2022 highlights isatin hybrids which have been synthesized and reported in the literature alongside a discussion on their biological properties. The enriched structure–activity relationship studies discussed provides insights for the rational design of novel isatin hybrids with tailored biological properties as effective therapeutic candidates inspired by nature.

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Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

Cited by 11 publications

References 111 publications

Lewis acid-mediated modular route to the synthesis of 3-substituted quinolines from 2-aminobenzyl alcohols and enamine(one)s

Lewis acid-mediated modular route to the synthesis of 3-substituted quinolines from 2-aminobenzyl alcohols and enamine(one)s

Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline

A survey of isatin hybrids and their biological properties

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