Exploring epigenetic strategies for the treatment of osteoporosis

Yi, Sun-Ju; Lim, Jaeho; Kim, Kyunghwan

doi:10.1007/s11033-024-09353-4

Mol Biol Rep

2024

DOI: 10.1007/s11033-024-09353-4

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Exploring epigenetic strategies for the treatment of osteoporosis

Sun-Ju Yi,

Jaeho Lim,

Kyunghwan Kim

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2024

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Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Liu,

Dong,

Zhou

et al. 2024

Sci Rep

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Background: Both lipid metabolism and obesity are crucial factors in osteoporosis, influencing the relevance of the cardiometabolic index (CMI), a new body fat index incorporating obesity and lipid metrics. Our study aims to explore the relationship between CMI and lumbar spine bone mineral density (BMD) and the mediating role of body fat percentage. Methods: Utilizing the National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2018, we conducted a cross-sectional analysis. We employed multiple linear regression models, subgroup analyses, generalized additive models (GAM), smooth curve fitting, and mediation analysis to evaluate the linear and nonlinear relationships between CMI and lumbar spine BMD. Results: The study involved 5,124 participants with an average lumbar spine BMD of 1.03 ± 0.15 g/cm 2 . We identified a negative correlation between CMI and lumbar spine BMD (β = -0.015; 95% CI: -0.023, -0.008). Nonlinear associations were evident, with inflection points at CMI values of 1.12 and 2.86. Subgroup analyses showed consistent negative correlations across all categories without significant differences (p for interaction > 0.05). Moreover, body fat percentage negatively correlated with BMD (β = -0.005; 95% CI: -0.006, -0.004) and mediated 9.41% of the relationship between CMI and BMD. Conclusion: Increased CMI levels are associated with lower lumbar spine BMD, with body fat percentage significantly mediating this relationship. This underscores the importance of managing body composition in the context of bone health, highlighting CMI’s potential utility in osteoporosis risk assessment.

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Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Liu,

Dong,

Zhou

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Exploring epigenetic strategies for the treatment of osteoporosis

Cited by 1 publication

References 181 publications

Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

Nonlinear relationship between cardiometabolic index and bone mineral density in U.S. adults: the mediating role of percent body fat

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