Exploring Excipients: Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods

Coyle, Robert; Farrell, Garrett F.; McFadden, Kim; Warren, P.

doi:10.1021/acs.jchemed.1c00233

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…A similar pitch in the past was made for including polymer science in the chemistry curriculum which is now taught in most chemistry coursework . The theory of sensing requires amalgamation of fluid dynamics, , molecular transport, , and binding kinetics. , Several theoretical and laboratory activities have been suggested for teaching these topics individually, − but a coherent introduction in chemistry coursework remains missing.…”

Section: Introductionmentioning

confidence: 99%

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A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors

Prakash

Varma

2022

J. Chem. Educ.

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The field of biosensors is a burgeoning area of research and employs a large number of chemistry graduates. The impact of strip tests in detecting coronavirus was palpable during the recent COVID-19 pandemic and will further drive the biosensor industry. Despite their common usage, a coherent introduction to the basics of sensing remains missing from the chemistry curriculum. Through this work, key concepts of transport and noise interference in molecular sensing aimed at upper-level coursework are introduced. Exercises including teamwork activities are proposed for teaching and inquiry-based learning. The presented approach was effective in solidifying the concepts of molecular transport and competing binding kinetics. Furthermore, students are introduced to an online database on biomarkers and open-source binding affinity resources. The material can be seamlessly integrated into the existing coursework by expanding discussions on binding kinetics and equilibrium.

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Section: Introductionmentioning

confidence: 99%

“…3 The theory of sensing requires amalgamation of fluid dynamics, 4,5 molecular transport, 6,7 and binding kinetics. 8,9 Several theoretical and laboratory activities have been suggested for teaching these topics individually, 4−9 but a coherent introduction in chemistry coursework remains missing.…”

Section: ■ Introductionmentioning

confidence: 99%

A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors

Prakash

Varma

2022

J. Chem. Educ.

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“…The use of mechanical stirrers in the laboratory ranges from small scale to large batch reactors. There have been numerous designs published in this Journal for overhead mechanical stirrers ranging from the use of bicycle parts and food mixers to other devices. − In some situations, such as the synthesis of magnetic particles or dissolution of tablets, , a magnetic stir plate is not ideal. Even a small-scale mechanical stirrer can be rather expensive, preventing its adoption for teaching laboratories.…”

Section: Introductionmentioning

confidence: 99%

Construction and Application of an Affordable “Light Duty” Overhead Mechanical Stirrer for the Teaching Laboratory

2022

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The overhead mechanical stirrer is a versatile and valuable tool for the laboratory. Even a low-end mechanical stirrer is rather expensive and can pose serious safety concerns for use by high school or undergraduate students. The construction and application of a low-cost overhead mechanical stirrer is described in this work. The mechanical stirrer is constructed using a commercially available USB powered minipottery wheel and other low-cost materials. The total cost of construction is less than $50 per stirrer. This overhead mechanical stirrer is designed for use with low to medium viscosity liquids. This stirrer has been successfully used in the synthesis of a ferrofluid in the Advanced Inorganic Chemistry laboratory at Radford University. The fabrication of the glass stirring shaft is used as an opportunity for students to learn scientific glassblowing skills.

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“…In the pharmaceutical industry, in vitro drug dissolution tests are typically performed with dissolution devices authorized by and following the standard protocol developed by the United States Pharmacopeia (USP) . Chemistry education studies have been conducted for implementing pharmaceutical analysis in teaching laboratories, particularly in the identification − and quantification of drug molecules − and introduction to drug design. − However, there are a limited number of laboratory experiments in dissolution testing developed for the undergraduate chemistry curriculum; , USP dissolution apparatuses are expensive, and it is not feasible to provide one instrument for each student group in the teaching lab. We decided to design a cost-effective apparatus and develop a dissolution protocol for the undergraduate teaching laboratory.…”

mentioning

confidence: 99%

Spectroscopic Monitoring and Modeling Drug Dissolution for Undergraduate Chemistry Curriculum

Guo,

Wendel,

Lee

et al. 2024

J. Chem. Educ.

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The pharmaceutical and medicine manufacturing industry has become the largest industrial sector for the employment of chemists, indicating a need for experiments with a pharmaceutical sciences context in the undergraduate chemistry curriculum. In the pharmaceutical industry, testing drug dissolution is a key analytical task for solid oral dosage forms that is performed in different phases of drug development to test the release behavior of new formulations, ensure consistency between manufacturing lots, and help predict the in vivo absorption of the drug substance after administration. However, there are a limited number of laboratory experiments in dissolution testing developed for the undergraduate chemistry curriculum. To help students obtain hands-on experience in dissolution testing, a protocol has been developed for an undergraduate chemistry laboratory course for students to build a dissolution apparatus, monitor dissolution processes, model the dissolution to extract kinetic parameters, and evaluate the consistency between dissolution curves with FDA regulated methods. Students successfully collected dissolution curves and completed the modeling analysis with nonlinear least-squares fitting. The designed dissolution protocol has been evaluated to have consistency and reproducibility to be implemented in the undergraduate chemistry laboratory curriculum.

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Exploring Excipients: Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods

Cited by 4 publications

References 14 publications

A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors

A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors

Construction and Application of an Affordable “Light Duty” Overhead Mechanical Stirrer for the Teaching Laboratory

Spectroscopic Monitoring and Modeling Drug Dissolution for Undergraduate Chemistry Curriculum

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