Exploring Existence of Host-Guest Inclusion Complex of β-Cyclodextrin of a Biologically Active Compound with the Manifestation of Diverse Interactions

Rahaman, Habibur; Roy, Niloy; Roy, Anshuman; Ray, Samapika; Roy, Mahendra Nath

doi:10.28991/esj-2018-01149

Cited by 7 publications

(2 citation statements)

References 24 publications

(25 reference statements)

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“…The inclusion complexation of UMB with αCD was prepared by applying the coprecipitation method. 27 A solution of αCD (1.38 g) and UMB (0.2 g) was prepared in 25 mL of double-distilled water in a 1:1 molar ratio and stirred at 55 °C for 48 h. The resulting clear solution was evaporated to dryness. Then, the white precipitate was filtered cautiously and washed with ethanol and water four times to eliminate uncomplexed UMB and αCD.…”

Section: Methodsmentioning

confidence: 99%

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body

et al. 2020

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In this study, umbelliferone and α-cyclodextrin host molecules have been mixed up through a coprecipitation method to prepare a supramolecular complex to provide physical insights into the formation and stability of the inclusion complex (IC). The prepared hybrid was characterized by 1H nuclear magnetic resonance (1H NMR), Fourier transform infrared (FTIR) spectroscopy, electrospray ionization (ESI) mass spectrometry, DSC, and fluorescence spectroscopic studies. Job’s plot provides a stoichiometric ratio of 1:1 and the Benesi–Hildebrand double reciprocal plot gives binding constant values using fluorescence spectroscopic titrations and the ESI mass data support the experimental observations. The results of molecular modeling were systematically analyzed to validate the inclusion complexation. In preliminary computational screening, α-cyclodextrin IC of umbelliferone was found to be quite stable based on the docking score, binding free energies, and dynamic simulations. In addition, the results obtained from 1H NMR and FTIR spectroscopy studies supported the inclusion complexation phenomenon. The results obtained from computational studies were found to be consistent with the experimental data to ascertain the encapsulation of umbelliferone into α-cyclodextrin.

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Section: Methodsmentioning

confidence: 99%

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body

et al. 2020

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“…Furthermore, the bioavailability of compounds has been defined as the fraction of a compound that is released from its matrix in the gastrointestinal tract and thus exhibits the oral absorption ability (Fernández-García, Carvajal-Lérida, & Pérez-Gálvez, 2009). The information from bioavailability studies would contribute to ensure or improve its nutritional efficacy (Rahaman, Roy, Roy, Ray, & Roy, 2018;Torres-Palazzolo et al, 2018). The present study was undertaken to investigate the bioavailability of pigments in "Laba" garlic.…”

Section: Introductionmentioning

confidence: 99%

Comparison of processing technology on quality of “Laba” garlic products

Guo

Zhao

et al. 2019

CyTA - Journal of Food

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In order to comparison of processing technology on quality of "Laba" garlic products, the garlic was dipped in acetic acid and fumigated by acetic acid with carbon dioxide, CO 2 , respectively, until became green. The pigment formation, texture characteristics, and bioactivities of "Laba" garlic was investigated. Garlic fumigated by acetic acid with 80% CO 2 exhibited the most discoloration, while the hardness and pigment bioavailability of garlic fumigated by acetic acid with 20% CO 2 presented the highest value. Correlation test showed that scavenging rate of DPPH• of garlic products is highly dependent on allicin content, while showed a good negative correlation between allicin content and blue, yellow pigments. Though formation of new pigments, the scavenging rate of DPPH• decreased indicating that pigments of "Laba" garlic exhibited much poorer clearance rate of DPPH• than allicin. In summary, "Laba" garlic fumigated with acetic acid and 20% CO 2 showed the best quality.Comparación de tecnologías de procesamiento en la calidad de los productos de ajo "Laba" RESUMEN Con el fin de comparar las tecnologías de procesamiento en la calidad de los productos de ajo "Laba", se sumergió el ajo en ácido acético y se fumigó con ácido acético con dióxido de carbono, CO 2 , respectivamente, hasta que se volvió verde. Posteriormente, se investigaron la formación de pigmentos, las características de la textura y las bioactividades del ajo "Laba". El ajo fumigado con ácido acético conteniendo 80% de CO 2 exhibió la mayor decoloración; por otra parte, la dureza y la biodisponibilidad del pigmento del ajo fumigado con ácido acético conteniendo 20% de CO 2 presentaron el valor más alto. La prueba de correlación mostró que la tasa de eliminación de DPPH• de productos de ajo es altamente dependiente del contenido de alicina, comprobándose una buena correlación negativa entre el contenido de alicina y los pigmentos azules y amarillos. La formación de nuevos pigmentos determinó que la tasa de eliminación de DPPH• disminuyera, lo que indica que los pigmentos de ajo "Laba" exhibieron una tasa de eliminación de DPPH• mucho menor que la alicina. En resumen, el ajo "Laba" fumigado con ácido acético y 20% de CO 2 mostró la mejor calidad.

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Improvement of the simple regression model for river’ EC estimation

Salarijazi

Ghorbani

2019

Arab J Geosci

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Exploring Existence of Host-Guest Inclusion Complex of β-Cyclodextrin of a Biologically Active Compound with the Manifestation of Diverse Interactions

Cited by 7 publications

References 24 publications

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body

Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body

Comparison of processing technology on quality of “Laba” garlic products

Improvement of the simple regression model for river’ EC estimation

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