Exploring Force-Driven Stochastic Folding Dynamics in Mechano-Responsive Proteins and Implications in Phenotypic Variation
Sabyasachi Rakshit,
Pritam Saha,
Vishavdeep Vashisht
et al.
Abstract:Single-point mutations are pivotal in molecular zoology, shaping functions and influencing genetic diversity and evolution. Here we study three such genetic variants of a mechano-responsive gating-spring protein, cadherin-23, that uphold the structural integrity of the protein, but showcase distinct genotypes and phenotypes. All-atom simulations indicated marginal deviations in the transient intra-domain interactions among the variants leading to variations in the anti-cross correlated motions among constituen… Show more
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